Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein promotes cancer metastasis and survival

20.04.2004


A new study demonstrates that a protein called periostin promotes deadly spreading and late stage progression of colon cancer. The research results demonstrate that periostin promotes metastatic growth of colon cancer by activating signaling molecules that encourage cell survival and identify the protein as a potential therapeutic target for the control of colon cancer.



Colorectal cancer commonly metastasizes to the liver and is the second leading cause of death from cancer in the United States. As with most cancers, it is the metastasis and not the primary tumor that is responsible for cancer fatality. However, the complex mechanisms associated with tumor metastasis are not very well understood. Dr. Xiao-Fan Wang from Duke University Medical Center and colleagues searched for genes associated with metastatic tumors in samples from primary and metastatic colon cancers and found that periostin was highly expressed in metastatic tumors. When periostin was introduced into human colon cancer cells grown in the laboratory, the cells were much more likely to metastasize to the liver when subsequently introduced into mice. The researchers went on to show that the underlying molecular mechanism for periostin-mediated tumor metastasis is related to an increase in survival of cancer and blood vessel cells under stressful conditions.

The researchers conclude that periostin plays a critical role in the progression of colon cancers and may be involved in metastasis of other cancers as well. "Metastasis accounts for the majority of the mortality associated with colorectal cancer, making control of metastasis an attractive treatment goal," explains Dr. Wang. "Our findings identify periostin as a potent promoter of late stage tumor progression. It is likely that periostin and similar types of proteins enable tumor cells to thrive in distant organs and grow under conditions that normally would be inhospitable. Targeting these proteins may prove to be a highly effective strategy for preventing late-stage progression of deadly metastatic cancers."



Shideng Bao, Gaoliang Ouyang, Xuefang Bai, Zhi Huang, Chaoyu Ma, Ming Liu, Rong Shao, Ryan M. Anderson, Jeremy N. Rich, and Xiao-Fan Wang: "Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway"

Published in Cancer Cell, Volume 5, Number 4, April 2004.

Heidi Hardman | EurekAlert!
Further information:
http://www.cell.com/

More articles from Health and Medicine:

nachricht Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>