Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of M researchers a step further in Type 1 diabetes treatment

23.02.2004


Single Infusion of islet cells surpasses previous success



esearchers at the University of Minnesota’s Diabetes Institute for Immunology and Transplantation (DIIT) and the University of California San Francisco (UCSF) Diabetes Center have achieved insulin independence in four of six patients with long-term Type 1 diabetes using one infusion of insulin-producing "islet" cells from a single donor pancreas.

Individuals in whom Type 1 diabetes was complicated by hypoglycemic unawareness participated in this trial. The combination of improved islet preparation techniques and optimized recipient immunosuppression contributed to the successful study outcome. Insulin independence has now been maintained for more than one year in four recipients, for more than two years in three recipients, and for more than three years in two recipients. The study, funded primarily by the Juvenile Diabetes Research Foundation, is published in the March issue of the American Journal of Transplantation.


"This success builds upon other recent successes in islet transplantation and marks a critical step in developing islet transplants into a vital treatment option for people with Type 1 diabetes", said Dr. Bernhard Hering, associate professor of surgery, holder of the Eunice L. Dwan Diabetes Research Chair at the University of Minnesota, and principal investigator of the study.

"This trial also brings us a step closer to minimizing the requirements for immunosuppression in islet transplant recipients," said Dr. Jeffrey Bluestone, professor of medicine and director of the Diabetes Center at UCSF, and co-principal investigator of the study.

Dr. Bluestone developed the new generation anti-CD3 monoclonal antibody that was administered in this trial during the first two weeks after transplant. This antibody is directed against the subset of white blood cells that cause Type 1 diabetes and mediate rejection of transplants. Study participants received two other immunosuppression drugs.

In a subsequent trial supported by the NIH Immune Tolerance Network (www.immunetolerance.org), the research team at the University of Minnesota and UCSF will test whether maintenance immunosuppressive medication can be minimized or even discontinued in islet transplant recipients given the anti-CD3 antibody.

"The demonstration in this pilot clinical trial that insulin independence can be induced in Type 1 diabetes with single donor islet transplants is quite important because it will allow an increased number of islet transplants to be performed, and at the same time, will decrease the risk and cost of the procedure", Richard Insel, M.D., executive vice president of research at the Juvenile Diabetes Research Foundation.


The Diabetes Institute for Immunology and Transplantation (DIIT) was formed in 1994 to capitalize on the University of Minnesota’s historic leadership in pancreas and islet cell transplantation. Both of these advanced treatments for diabetes were pioneered here. Under the leadership of David E.R. Sutherland, M.D., Ph.D., both procedures have continued to be refined. The University of Minnesota is the home of the world’s oldest, largest pancreas transplant program, having performed over 1,500 pancreas transplants, which are frequently preceded, accompanied or succeeded by a kidney transplant.

Molly Portz | EurekAlert!
Further information:
http://www.blackwellpublishing.com,
http://www.diabetesinstitute.org.
http://www.immunetolerance.org

More articles from Health and Medicine:

nachricht Nitric oxide-scavenging hydrogel developed for rheumatoid arthritis treatment
06.06.2019 | Pohang University of Science & Technology (POSTECH)

nachricht Infants later diagnosed with autism follow adults’ gaze, but seldom initiate joint attention
24.05.2019 | Schwedischer Forschungsrat - The Swedish Research Council

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

Im Focus: Tube anemone has the largest animal mitochondrial genome ever sequenced

Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.

The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....

Im Focus: Tiny light box opens new doors into the nanoworld

Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.

Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Uncovering hidden protein structures

18.06.2019 | Life Sciences

Monitoring biodiversity with sound: how machines can enrich our knowledge

18.06.2019 | Life Sciences

Schizophrenia: Adolescence is the game-changer

18.06.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>