Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New study uses genetic profiling to predict breast cancer patients’

02.06.2003


Researchers at the Breast Care Center at Baylor College of Medicine and The Methodist Hospital have developed a new test to predict which breast cancer tumors will respond to chemotherapy, potentially reducing unnecessary treatment for women with breast cancer, according to data presented at the American Society of Clinical Oncology annual meeting in Chicago.



Using novel DNA array technology, the study identified differences in the gene patterns from tumor samples that predict which patients would respond to treatment with the chemotherapy docetaxel, marketed under the brand name Taxotere by Aventis.

After studying pretreatment biopsies from 24 patients and their genes after treatment, results show that tumors responding to Taxotere show a different pattern than tumors that had not responded to drug therapy. In the study, 88 percent of the genes were correctly classified, said Dr. Jenny Chang, an assistant professor of medicine at Baylor. This study marks the first time microarray technology has been used to study breast cancer tumor response to a chemotherapeutic agent.


"We may have a clinically useful predictive test for chemotherapy sensitivity that may allow us to prioritize breast cancer treatment strategies based on their likelihood of success," said Chang. "This research, if validated, may lead to important advances in the treatment of breast cancer including reducing unnecessary treatment for some women, while optimizing therapy for others."

The team of investigators, led by Chang, studied thousands of genes with new DNA array technology, to find the differences between tumors that responded to Taxotere chemotherapy and those tumors that failed to respond. This finding confirmed that breast cancers are not all alike, and treatment can be tailored to individual tumors.

"We are trying not only to understand the disease, but also how a patient’s tumor may respond to a treatment even before we select a chemotherapy. As opposed to acquired resistance, which builds up with months of therapy, these results show that some women will be resistant to the drug from day one," Chang said. "Once confirmed in a larger study, this type of molecular profiling could have profound clinical applications in defining optimal treatment selection for each individual patient."

Chemotherapy, designed to eliminate cancer cells that have spread, is beneficial in reducing the risk of death in many patients with early breast cancer, but physicians have long had trouble figuring out which patients would benefit from the treatment, she said. As a result, some breast cancer patients needlessly receive chemotherapy after surgery. Chemotherapy can have serious side effects, including nausea, vomiting, hair loss, diarrhea, nerve damage and infections.

Stefanie Asin | EurekAlert!
Further information:
http://research.bcm.tmc.edu/

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>