Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Microparticles cause pre-eclampsia

24.01.2003


Vessel wall cells and blood cells have been found to release cell particles which can damage blood vessels. This was demonstrated in laboratory experiments carried out by Marja van Wijk during her doctoral research at the University of Amsterdam. Poorly functioning blood vessels play a role in pre-eclampsia.



For her research (conducted at the Academic Medical Centre, University of Amsterdam) Van Wijk isolated blood vessels from pieces of tissue taken from pregnant women. She placed the blood vessels in a solution of microparticles isolated from the blood of pregnant women with and without pre-eclampsia. A so-called wire myograph was then used to measure the functioning of the blood vessels.

Vessels in a solution of ’affected’ microparticles were found to function less well than vessels with ’healthy’ particles. Which microparticles or parts thereof are responsible for the vessel damage is not clear. Exactly how the particles are formed must also be investigated.


Van Wijk’s research has also revealed that it is not just the inner lining of the vessel wall which functions inadequately during pre-eclampsia. The smooth muscle cells on the outside of the vessels also function less effectively. These muscle cells are responsible for the contraction of the vessels.

Van Wijk also investigated the effect of oestrogen on blood vessels. The administration of oestrogen to isolated vessels taken from women with pre-eclampsia, improved the functioning of the inner lining of the vessel walls. However, whether the administration of oestrogen can help to control pre-eclampsia is not yet clear.

Worldwide, pre-eclampsia is one of the most important causes of mortality of the mother and/or child during pregnancy. Blood from women with pre-eclampsia contains more microparticles from white blood cells than that of women without pre-eclampsia. These microparticles could originate, for example, from leucocytes which pass through an affected placenta. The microparticles can activate other cells, which in turn release particles, or directly disrupt the functioning of the blood vessels.

The research was partially funded by the Netherlands Organisation for Scientific Research (NWO).

Michel Philippens | alfa
Further information:
http://www.nwo.nl

More articles from Health and Medicine:

nachricht Deep stimulation improves cognitive control by augmenting brain rhythms
04.04.2019 | Picower Institute at MIT

nachricht Black nanoparticles slow the growth of tumors
04.04.2019 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

New automated biological-sample analysis systems to accelerate disease detection

18.04.2019 | Life Sciences

Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

18.04.2019 | Physics and Astronomy

New eDNA technology used to quickly assess coral reefs

18.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>