Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Microparticles cause pre-eclampsia

24.01.2003


Vessel wall cells and blood cells have been found to release cell particles which can damage blood vessels. This was demonstrated in laboratory experiments carried out by Marja van Wijk during her doctoral research at the University of Amsterdam. Poorly functioning blood vessels play a role in pre-eclampsia.



For her research (conducted at the Academic Medical Centre, University of Amsterdam) Van Wijk isolated blood vessels from pieces of tissue taken from pregnant women. She placed the blood vessels in a solution of microparticles isolated from the blood of pregnant women with and without pre-eclampsia. A so-called wire myograph was then used to measure the functioning of the blood vessels.

Vessels in a solution of ’affected’ microparticles were found to function less well than vessels with ’healthy’ particles. Which microparticles or parts thereof are responsible for the vessel damage is not clear. Exactly how the particles are formed must also be investigated.


Van Wijk’s research has also revealed that it is not just the inner lining of the vessel wall which functions inadequately during pre-eclampsia. The smooth muscle cells on the outside of the vessels also function less effectively. These muscle cells are responsible for the contraction of the vessels.

Van Wijk also investigated the effect of oestrogen on blood vessels. The administration of oestrogen to isolated vessels taken from women with pre-eclampsia, improved the functioning of the inner lining of the vessel walls. However, whether the administration of oestrogen can help to control pre-eclampsia is not yet clear.

Worldwide, pre-eclampsia is one of the most important causes of mortality of the mother and/or child during pregnancy. Blood from women with pre-eclampsia contains more microparticles from white blood cells than that of women without pre-eclampsia. These microparticles could originate, for example, from leucocytes which pass through an affected placenta. The microparticles can activate other cells, which in turn release particles, or directly disrupt the functioning of the blood vessels.

The research was partially funded by the Netherlands Organisation for Scientific Research (NWO).

Michel Philippens | alfa
Further information:
http://www.nwo.nl

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>