Researchers funded by the National Institute of General Medical Sciences have determined the structure of a protein with a surprising feature in it: a knot. This is the first time a knot has been found in a protein from the most ancient type of single-celled organism, an archaebacterium, and one of only a few times a knot has been seen in any protein structure.
This very unusual protein shape finding is a result from the NIGMS Protein Structure Initiative, a 10-year effort to determine 10,000 unique protein structures using fast, highly automated methods. NIGMS, a component of the U.S. Department of Health and Human Services National Institutes of Health, provides $50 million per year to nine PSI research centers. The protein knot structure was solved at one of the PSI centers, the Midwest Center for Structural Genomics, which is directed by Andrzej Joachimiak, Ph.D., of Argonne National Laboratory in suburban Chicago.
The researchers describe the new protein structure in the journal Proteins. Their article will be published online Nov. 27 and in print in early December.
Linda Joy | EurekAlert!
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