A genetic variant that can explain the occurrence of a type of rheumatic disorder called SLE has been identified by a research team at Uppsala University, Sweden. The team, led by Associate Professor Marta Alarcón at the Rudbeck Laboratory, is presenting its finding in the latest issue of the scientific journal Nature Genetics.
Nearly 6,000 predominantly young women are victims of systemic lupus erythematosus, SLE. The disease is partly genetic and causes damage to the skin and various organs. The genetic variant in the gene PDCD1 was identified in families with at least two persons suffering from the ailment. Genetic analyses have shown that the part where the gene PDCD1 is located in chromosome 2 is implicated in the disease.
The research team has determined the position of the gene with still greater precision and has sequenced the whole gene. They found several variants, but only one of them repeatedly turned up in the family members with the sickness. In order to make certain that the variant is associated with the ailment, the team studied nearly 2,500 individuals including families in the US. The variant is found in some of the patients and can explain one of the mechanisms behind the development of the disease. The genetic variant in the PDCD1 gene can modify the normal function and expression of the gene, but it is still unclear exactly how.
Jon Hogdal | alfa
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences