Treatment with a common diabetes drug effectively shrank these tumors in mice
While most cases of a hormonal disorder called Cushings Syndrome are caused by non-cancerous pituitary tumors that secrete too much of a particular hormone resulting in high cortisol levels, the disorder can ultimately lead to an early death for many patients whose tumors cannot be removed surgically.
Now, researchers at Cedars-Sinai Medical Center have found that pituitary tumors express an abundance of a specific protein receptor and report that treatment with a common diabetes drug was effective in shrinking tumor size and reducing hormone production in Cushings pituitary tumors in mice. The findings, reported in the November issue of the journal, Nature Medicine, may lead to a new way to treat patients who have Cushings Syndrome.
Kelli Stauning | Cedars-Sinai Medical Center
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A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
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