Mouse studies indicate successful pain relief, University of Pittsburgh researchers say
By "programming" a herpes simplex virus to deliver a gene-mediated pain-blocking protein at the cellular level, University of Pittsburgh researchers have been able to significantly reduce cancer-related pain in mice with tumors, the researchers report in the November issue of the journal Annals of Neurology. The paper, "Herpes vector-mediated expression of proenkephalin reduces bone cancer pain," is now available online at the journals Web site, http://www.interscience.wiley.com/jpages/0364-5134/.
"Chronic pain is notoriously difficult to treat effectively," said co-author Joseph Glorioso, Ph.D., chairman of the department of molecular genetics and biochemistry and director of the Molecular Medicine Institute at the University of Pittsburgh School of Medicine, and president of the American Society of Gene Therapy. "Weve been able to show that using this virus can significantly reduce bone cancer pain – at least in mice."
Michele Baum | EurekAlert!
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