Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cell transplants look promising for stroke recovery

27.08.2002


Using transplants of bone marrow cells improved the recovery from stroke in rat experiments, according to a study published in the August 27 issue of Neurology, the scientific journal of the American Academy of Neurology.



The rats treated with an intravenous transplant of adult human stromal cells (mature cells from bone marrow) had significant improvements in their ability to function 14 days after the stroke, compared to rats that did not receive transplants after a stroke.

"These are smart cells that selectively migrate to the site of injury and become little factories producing an array of helpful molecules to repair the tissue," said study author Michael Chopp, PhD, of Henry Ford Hospital in Detroit, Mich., and Oakland University in Rochester, Mich. "We believe this therapy shows promise in treating stroke, Parkinson’s disease, spinal cord injury and traumatic brain injury."


For the study, bone marrow cells were taken from three healthy human donors. Strokes were then induced in the rats and they were given the cells intravenously one day after the stroke. Other groups treated with fibroblast cells or not treated served as controls.

The rats were tested on their motor and sensory abilities and on their reflexes before the stroke and at one day, seven days and 14 days after the stroke. In a test of sensory abilities 14 days after the stroke, the rats treated with marrow stromal cells completed the test 60 percent faster than the non-treated rats. A detailed neurological examination showed that 14 days after the stroke the treated rats had a 30-percent improvement in overall neurological score compared to the control rats.

Compared to the control rats, the rats receiving marrow stromal cells produced more neurotrophic factors and nerve growth factors that stimulate cells to grow. They also had less cell death in the area of the stroke than the control rats. Chopp said the next step is to test the procedure in small numbers of humans to make sure it is safe. Marrow stromal cells have been used in human cancer patients.

The treatment is exciting in part because it appears to give doctors a longer time window to treat stroke patients than current treatments, according to neurologist and stroke recovery researcher Thomas A. Kent, MD, of the University of Texas Medical Branch in Galveston, Texas, who wrote an editorial accompanying the article.

"It’s very difficult to treat people with a stroke within a narrow time window," he said. "Many people still don’t recognize the symptoms of stroke and get to an emergency room quickly enough for treatment. If this new treatment is effective, it could expand the treatment window by several hours or even longer."

Kent cautioned, however, that more studies are needed to determine the long-term effects of the transplants.

Cheryl Alementi | EurekAlert!

More articles from Health and Medicine:

nachricht Cancer cells make blood vessels drug resistant during chemotherapy
02.07.2020 | Hokkaido University

nachricht Novel potassium channel activator which acts as a potential anticonvulsant discovered
02.07.2020 | The Mount Sinai Hospital / Mount Sinai School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electrons in the fast lane

Solar cells based on perovskite compounds could soon make electricity generation from sunlight even more efficient and cheaper. The laboratory efficiency of these perovskite solar cells already exceeds that of the well-known silicon solar cells. An international team led by Stefan Weber from the Max Planck Institute for Polymer Research (MPI-P) in Mainz has found microscopic structures in perovskite crystals that can guide the charge transport in the solar cell. Clever alignment of these "electron highways" could make perovskite solar cells even more powerful.

Solar cells convert sunlight into electricity. During this process, the electrons of the material inside the cell absorb the energy of the light....

Im Focus: The lightest electromagnetic shielding material in the world

Empa researchers have succeeded in applying aerogels to microelectronics: Aerogels based on cellulose nanofibers can effectively shield electromagnetic radiation over a wide frequency range – and they are unrivalled in terms of weight.

Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic...

Im Focus: Gentle wall contact – the right scenario for a fusion power plant

Quasi-continuous power exhaust developed as a wall-friendly method on ASDEX Upgrade

A promising operating mode for the plasma of a future power plant has been developed at the ASDEX Upgrade fusion device at Max Planck Institute for Plasma...

Im Focus: ILA Goes Digital – Automation & Production Technology for Adaptable Aircraft Production

Live event – July 1, 2020 - 11:00 to 11:45 (CET)
"Automation in Aerospace Industry @ Fraunhofer IFAM"

The Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM l Stade is presenting its forward-looking R&D portfolio for the first time at...

Im Focus: AI monitoring of laser welding processes - X-ray vision and eavesdropping ensure quality

With an X-ray experiment at the European Synchrotron ESRF in Grenoble (France), Empa researchers were able to demonstrate how well their real-time acoustic monitoring of laser weld seams works. With almost 90 percent reliability, they detected the formation of unwanted pores that impair the quality of weld seams. Thanks to a special evaluation method based on artificial intelligence (AI), the detection process is completed in just 70 milliseconds.

Laser welding is a process suitable for joining metals and thermoplastics. It has become particularly well established in highly automated production, for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International conference QuApps shows status quo of quantum technology

02.07.2020 | Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

 
Latest News

Rising water temperatures could endanger the mating of many fish species

03.07.2020 | Life Sciences

Risk of infection with COVID-19 from singing: First results of aerosol study with the Bavarian Radio Chorus

03.07.2020 | Studies and Analyses

Efficient, Economical and Aesthetic: Researchers Build Electrodes from Leaves

03.07.2020 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>