Genetically fattened Zucker fa/fa rats
© University of the Basque Country
The Department of Nutrition and Bromatology of the Faculty of Pharmacy of Gasteiz, University of the Basque Country, is studying the action mechanism of fluoxetine in genetically fattened rats (Zucker fa/fa). Due to fluoxetine, those rats eat 50 % less. Therefore, the bodies put on less weight and the size of different fat tissues is reduced.
Antidepressants of the type of fluoxetine reduce appetite. More exactly, fluoxetine affects on neuropeptides that regulate appetite. Hence, it is believed that fluoxetine can be used to treat obesity.
After studying the action-mechanism of fluoxetine it has been observed that it reduces the quantity of Y neuropeptide. That peptide is orexigen, it causes appetite. The fluoxetine does hinders the trasport of that peptide, and so appetite is reduced.
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