Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Precancerous Stem Cells Can Form Tumor Blood Vessels

20.02.2008
Tumors require a blood supply to grow, but how they acquire their network of blood vessels is poorly understood. A new study here shows that tumor blood vessels can develop from precancerous stem cells, a recently discovered type of cell that can either remain benign or become malignant.

Researchers say the findings provide new information about how tumors develop blood vessels, and why new drugs designed to block tumor blood-vessel growth are often less effective than expected.

The study by scientists at the Ohio State University Comprehensive Cancer Center and Department of Pathology is to be published Feb. 20 in the journal PLoS ONE. “These findings suggest that tumor blood vessels are derived mainly from tumor cells, with a smaller number coming from normal blood-vessel cells,” says principal investigator Jian-Xin Gao, assistant professor of pathology.

“This may explain why many anti-angiogenic drugs fail to block tumor growth.”

Gao notes that potential anti-angiogenic drugs are usually screened using normal blood-vessel cells, also called endothelial cells, or their progenitors.

“The screened drugs may be very good at blocking the formation of blood vessels made by normal endothelial cells, but have little effect on blood-vessel formation by precancerous stem cells or other blood-vessel-forming cancer cells,” Gao says. “Our findings suggest that screening of these agents should include precancerous stem cells.”

Normal stem cells are unspecialized cells that can give rise to other types of cells. Recent evidence suggests that tumors consist of a small number of cancerous stem cells, or cancer-propagating cells with some features of stem cells, and a large number of their malignant progeny.

Precancerous stem cells are thought to be cells that can remain noncancerous or progress to cancer, depending on subsequent environmental influences.

For this study, Gao and his colleagues used mouse precancerous stem cells grown in the laboratory and transplanted into immune-deficient mice. The researchers removed the resulting tumors from the mice and, using tests for various molecular markers, observed that the tumor blood vessels were largely derived from precancerous stem cells.

“The tumor blood-vessel cells were abnormal and highly variable in appearance compared with normal cells,” Gao says.

The precancerous stem cells also produced similar levels of substances that stimulate blood-vessel growth (i.e., angiogenic factors), but they were much more potent in forming new blood vessels and larger tumor masses compared with tumors grown from typical tumor cells.

The researchers examined new blood vessel formation in human tumors transplanted into mice, and observed changes similar to those previously seen in the mouse tumors.

Lastly, the researchers examined the appearance of blood vessels in human cervical and breast tumors and observed that the blood-vessel cells displayed similar abnormalities and aberrant patterns of molecular markers.

“This suggests that the ability of these tumors to form blood vessels is likely linked to precancerous stem cells or other blood-vessel-forming tumor cells,” Gao says.

Citation: Shen R, Ye Y, Chen L, Yan Q, Barsky SH, et al (2008) Precancerous Stem Cells Can Serve As Tumor Vasculogenic Progenitors. PLoS ONE 3(2): e1652.doi:10.1371/journal.pone.0001652

Andrew Hyde | alfa
Further information:
http://www.plosone.org/doi/pone.0001652
http://www.plosone.org

More articles from Health and Medicine:

nachricht Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern

nachricht Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The taming of the light screw

DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.

The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...

Im Focus: Magnetic micro-boats

Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.

The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Solving the efficiency of Gram-negative bacteria

22.03.2019 | Life Sciences

Bacteria bide their time when antibiotics attack

22.03.2019 | Life Sciences

Open source software helps researchers extract key insights from huge sensor datasets

22.03.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>