Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Precancerous Stem Cells Can Form Tumor Blood Vessels

20.02.2008
Tumors require a blood supply to grow, but how they acquire their network of blood vessels is poorly understood. A new study here shows that tumor blood vessels can develop from precancerous stem cells, a recently discovered type of cell that can either remain benign or become malignant.

Researchers say the findings provide new information about how tumors develop blood vessels, and why new drugs designed to block tumor blood-vessel growth are often less effective than expected.

The study by scientists at the Ohio State University Comprehensive Cancer Center and Department of Pathology is to be published Feb. 20 in the journal PLoS ONE. “These findings suggest that tumor blood vessels are derived mainly from tumor cells, with a smaller number coming from normal blood-vessel cells,” says principal investigator Jian-Xin Gao, assistant professor of pathology.

“This may explain why many anti-angiogenic drugs fail to block tumor growth.”

Gao notes that potential anti-angiogenic drugs are usually screened using normal blood-vessel cells, also called endothelial cells, or their progenitors.

“The screened drugs may be very good at blocking the formation of blood vessels made by normal endothelial cells, but have little effect on blood-vessel formation by precancerous stem cells or other blood-vessel-forming cancer cells,” Gao says. “Our findings suggest that screening of these agents should include precancerous stem cells.”

Normal stem cells are unspecialized cells that can give rise to other types of cells. Recent evidence suggests that tumors consist of a small number of cancerous stem cells, or cancer-propagating cells with some features of stem cells, and a large number of their malignant progeny.

Precancerous stem cells are thought to be cells that can remain noncancerous or progress to cancer, depending on subsequent environmental influences.

For this study, Gao and his colleagues used mouse precancerous stem cells grown in the laboratory and transplanted into immune-deficient mice. The researchers removed the resulting tumors from the mice and, using tests for various molecular markers, observed that the tumor blood vessels were largely derived from precancerous stem cells.

“The tumor blood-vessel cells were abnormal and highly variable in appearance compared with normal cells,” Gao says.

The precancerous stem cells also produced similar levels of substances that stimulate blood-vessel growth (i.e., angiogenic factors), but they were much more potent in forming new blood vessels and larger tumor masses compared with tumors grown from typical tumor cells.

The researchers examined new blood vessel formation in human tumors transplanted into mice, and observed changes similar to those previously seen in the mouse tumors.

Lastly, the researchers examined the appearance of blood vessels in human cervical and breast tumors and observed that the blood-vessel cells displayed similar abnormalities and aberrant patterns of molecular markers.

“This suggests that the ability of these tumors to form blood vessels is likely linked to precancerous stem cells or other blood-vessel-forming tumor cells,” Gao says.

Citation: Shen R, Ye Y, Chen L, Yan Q, Barsky SH, et al (2008) Precancerous Stem Cells Can Serve As Tumor Vasculogenic Progenitors. PLoS ONE 3(2): e1652.doi:10.1371/journal.pone.0001652

Andrew Hyde | alfa
Further information:
http://www.plosone.org/doi/pone.0001652
http://www.plosone.org

More articles from Health and Medicine:

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

nachricht Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Epoxy compound gets a graphene bump

14.11.2018 | Materials Sciences

Microgel powder fights infection and helps wounds heal

14.11.2018 | Health and Medicine

How algae and carbon fibers could sustainably reduce the athmospheric carbon dioxide concentration

14.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>