Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Prolactin reduces fat metabolism

02.04.2009
The hormone prolactin is necessary for the production of breast milk, but it also affects adipose (fatty) tissue and the body's metabolism. This has been shown by a thesis from the Sahlgrenska Academy, University of Gothenburg, Sweden. Raised prolactin levels in a woman who is not pregnant or breast feeding reduces lipid (fat) metabolism.

Over 30 000 Swedish men and women may have raised levels of prolactin. Women who are pregnant or breast feeding have naturally raised levels of prolactin, but stress, some medicines and benign brain tumours can also lead to raised levels of the hormone.

In many cases doctors don't know what causes the rise in hormone levels. In women, an abnormally high level can cause menstrual disturbances and infertility, and may also result in insulin resistance.

"In recent years scientists have also recognised the role of prolactin in the development of obesity, but little research has been done into the precise mechanism by which prolactin regulates metabolism," says Louise Nilsson.

In her thesis Louise Nilsson shows that there are receptors for the breast feeding hormone in human fatty tissue.

"We have demonstrated that prolactin reduces the ability of fatty tissue to store sugar and fat, which then could accumulate in the blood and certain tissues instead. This in turn increases the risk of cardiovascular disease."

Prolactin also affects the body's ability to metabolise fat. An ongoing study suggests that the hormone impairs the body's ability to maintain a balanced metabolism.

"When fatty tissue receives signals from prolactin, it reacts by reducing the production of another hormone called adiponectin, which is important for the metabolism of a variety of nutrients," explains Louise Nilsson.

FACTS ABOUT PROLACTIN
Prolactin is a hormone produced by the pituitary gland in the brain. It stimulates the production of milk in the breast and also inhibits hormone production in the ovaries and testicles. Prolactin levels are considerably raised in pregnancy, and prolactin secretion is also stimulated by breast feeding.

The Sahlgrenska Academy is the faculty of health sciences at the University of Gothenburg, Sweden. Education and research are conducted within the fields of pharmacy, medicine, odontology and health care sciences.

About 4000 undergraduate students and 1000 postgraduate students are enrolled at Sahlgrenska Academy. The staff is about 1500 persons. 850 of them are researchers and/or teachers.

For further information please contact:
Louise Nilsson, tel: +46 (0)31 786 3533, +46 (0)70 523 67 41, e-mail: louise.nilsson@gu.se
Supervisor:
Professor Håkan Billig, tel: +46 (0)31 786 3534, e-mail: hakan.billig@fysiologi.gu.se

Doctoral thesis from the Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden.

Title of thesis: Effects of prolactin on metabolism - changes induced by hyperprolactinemia

The thesis has been defended.
Link to the thesis: http://hdl.handle.net/2077/19049
Press information: Elin Lindström Claessen
Tel: +46 (0)31 786 3837, +46 (0)70 829 43 03
e-mail: elin.lindstrom@sahlgrenska.gu.se
The thesis is based on the following papers:
I Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits
lipoprotein lipase activity in human white adipose tissue.
Ling C, Svensson L, Odén B, Weijdegård B, Edén B, Edén S, Billig H.
J Clin Endocrinol Metab. 2003 Apr;88(4):1804-8.
II Prolactin suppresses malonyl-CoA concentration in human adipose tissue.
Nilsson L, Roepstorff C, Kiens B, Billig H, Ling C.
Submitted
III Prolactin and growth hormone regulate adiponectin secretion and receptor
expression in adipose tissue.
Nilsson L, Binart N, Bohlooly-Y M, Bramnert M, Egecioglu E, Kindblom J, Kelly
PA, Kopchick JJ, Ormandy CJ, Ling C, Billig H.
Biochem Biophys Res Commun. 2005 Jun 17;331(4):1120-6.
IV Suppressed lipid oxidation in women with pathological hyperprolactinemia.
Nilsson L, Bramnert M, Wessman Y, Billig H, Ling C.
Manuscript

Helena Aaberg | idw
Further information:
http://hdl.handle.net/2077/19049
http://www.gu.se/

More articles from Health and Medicine:

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

nachricht Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

NASA keeps watch over space explosions

16.11.2018 | Physics and Astronomy

UNH scientists help provide first-ever views of elusive energy explosion

16.11.2018 | Physics and Astronomy

How the gut ‘talks’ to brown fat

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>