Blood clots in veins and arteries can lead to heart attack, stroke, and pulmonary embolism, which are major causes of mortality. In the featured article of The Journal of Nuclear Medicine's (JNM) July 2017 issue, German researchers show that targeting GPIIb/IIIa receptors, the key receptor involved in platelet clumping, with a fluorine-18 (18F) labeled ligand is a promising approach for diagnostic imaging. Current imaging modalities rely on structural characteristics, such as vascular flow impairment, and do not address the critical molecular components.
"Currently available diagnostic techniques of thrombus [blood clot] imaging rely on different modalities depending on the vascular territory," explains Andrew W. Stephens, MD, PhD, of Piramal Imaging GmbH, Berlin, Germany. "A single imaging modality that could visualize thrombi from various sources in different anatomic regions would be very valuable."
For this preclinical study, researchers successfully developed the novel small molecule tracer 18F-GP1 for positron emission tomography (PET) imaging that binds with high affinity to GPIIb/IIIa receptors. 18F-GP1 showed a strong accumulation at the site of thrombus formation, and its binding ability was not affected by anticoagulants such as aspirin and heparin. The tracer showed rapid blood clearance, and PET imaging in a Cynomolgus monkey model demonstrated the detection of small venous and arterial clots, endothelial damage and emboli in the brain.
Due to the favorable pre-clinical results, a first-in-human study of 18F-GP1 is currently underway. Early results from an interim analysis confirm the preclinical data and were presented at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) in June.
"Although the current studies are preliminary, 18F-GP1 may provide not only more accurate anatomic localization, but also information of the risk of the clot growth or embolization," Stephens points out. "This may lead to changes in clinical intervention to the individual patient." Addressing the use of anticoagulants to treat blood clots, he notes, "These drugs can cause significant and life-threatening bleeding. There is a critical need to balance the risk of bleeding against the risk of clotting in each patient. 18F-GP1 may in the future assist in this important decision."
The authors of "18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi" include Jessica Lohrke, Holger Siebeneicher, Markus Berger, Michael Reinhardt, Marcus Bauser, and Joachim Huetter of Bayer AG, Drug Discovery, Berlin, Germany, and Mathias Berndt, Andre Mueller, Marion Zerna, Norman Koglin, Felix Oden, Matthias Friebe, Ludger M. Dinkelborg, and Andrew W. Stephens of Piramal Imaging GmbH, Berlin, Germany.
This study was funded by Bayer Pharma AG and Piramal Imaging GmbH, Berlin, Germany.
Please visit the SNMMI Media Center (http://www.
About the Society of Nuclear Medicine and Molecular Imaging
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and medical organization dedicated to raising public awareness about nuclear medicine and molecular imaging, a vital element of today's medical practice that adds an additional dimension to diagnosis, changing the way common and devastating diseases are understood and treated and helping provide patients with the best health care possible.
SNMMI's more than 17,000 members set the standard for molecular imaging and nuclear medicine practice by creating guidelines, sharing information through journals and meetings and leading advocacy on key issues that affect molecular imaging and therapy research and practice. For more information, visit http://www.
Laurie Callahan | EurekAlert!
The cytoskeleton of neurons has been found to be involved in Alzheimer's disease
18.01.2019 | University of the Basque Country
Bioinspired nanoscale drug delivery method developed by WSU, PNNL researchers
10.01.2019 | Washington State University
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
16.01.2019 | Event News
14.01.2019 | Event News
12.12.2018 | Event News
18.01.2019 | Materials Sciences
18.01.2019 | Life Sciences
18.01.2019 | Health and Medicine