Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New genes for regulating the heart rhythm discovered

02.07.2014

Cardiac arrhythmia is a frequent occurrence: according to the WHO, 33.5 million people all over the world are affected by atrial fibrillation - this being just one of many different kinds of arrhythmia.

A global research consortium, of which the EURAC Center for Biomedicine in Bozen-Bolzano is a member, has now identified 23 new genes which control both the heart rhythm and the length of the so-called QT interval. The study was further enhanced by data provided by participants from South Tyrol. The results, which open up new pathways for early diagnosis and treatment, have just been published in the medical journal “Nature Genetics”.

The QT interval is part of the heart’s electrical cycle as measured by ECG, and represents the electrical depolarization and repolarization of the ventricles. Lengthened intervals indicate dysfunction in the heart beat and are liable to lead to a five-fold increase in the risk of sudden death from heart failure. The underlying causes for such irregularities have not yet been fully explored. They are generally supposed to be due mainly to genetic factors.

In collaboration with research partners recruited from an international consortium, scientists from the EURAC Center for Biomedicine have evaluated the ECG results of over 100,000 study participants from Germany, Italy and the USA, as well as around 1,300 from South Tyrol who made their data freely available to the EURAC researchers. The scientists compared the QT intervals from the ECGs of all the study participants with their genetic variants in order to identify possible connections.

The result: they discovered 23 new genes which are linked to a lengthened QT interval. At the same time, they were able to demonstrate that the newly identified genes, which previously had not been thought to play a part in the heart rhythm, had a significant influence on the electrical activity of the heart muscle. In more in-depth studies with heart disease patients, the researchers could additionally determine that two of the newly identified genes were indeed risk factors for the disease known as “Long QT syndrome”.

“We still need to look more closely at the interplay of these genes with other risk factors, such as medication or life style. But one thing is certain: these findings have definitely brought us a great deal closer to recognising the causes of arrhythmia and sudden death from heart failure,” stress the two scientists Peter Pramstaller, manager of the EURAC Center for Biomedicine and his deputy, Andrew Hicks.

“With data from more than 100,000 participants in the study and the joint efforts of hundreds of international researchers, this represents one of the biggest global research projects on this topic to which we were able to contribute through both our scientific expertise as well as making data available from South Tyrol participants,” summarise Pramstaller and Hicks.

Another current study carried out by the EURAC Center for Biomedicine will provide further important insights into arrhythmia and sudden death from heart failure. Here, researchers are examining a protein, also identified in the QT study, which transports calcium within the cells in a pump-like action and can therefore be considered one of the most important proteins for a correctly functioning heart cell.

Weitere Informationen:

http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3014.html - Article "Nature Genetics"

Laura Defranceschi | idw - Informationsdienst Wissenschaft
Further information:
http://www.eurac.edu

Further reports about: ECG EURAC Genetics Nature death depolarization genes identify medication rhythm

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>