Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

14.09.2017

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.


Multi-well tissue plate (48-well format) for automated cardiotoxic or drug screening. In each well a fully functional heart muscle tissue ring has been produced around two flexible pins, which can be easily monitored by automated video analysis. Source: T. Meyer.

This lab innovation is based on previous scientific work from the group of Prof. Dr. Wolfram-Hubertus Zimmermann, Director of the Institute for Pharmacology and Toxicology at the UMG. Under the terms of the non-exclusive license agreement UMG will receive an upfront payment and, besides royalties, annual minimum license fees.

Unwanted side effects affecting the heart are among the most common causes for the high attrition rate in drug development. Furthermore, cardiovascular diseases are the major cause of death in Germany, accounting for almost 40% of the annual mortalities. Hence, preclinical testing for both cardiac toxicity as well as drug efficacy is an important precondition for successful drug development. Currently, these tests are primarily performed in cell cultures or animal models.

Because these models do not accurately reflect human physiology, there is a concern of limited predictive value as to clinical relevance of the obtained knowledge. Instead, tissue-engineered and lab-grown human tissues can much better reflect physiological conditions.

The newly developed multi-well tissue plate at UMG (currently at a 48-well format) allows for a standardized generation of human heart muscle under defined conditions from stem cells in a simple one-step procedure. The culture format was designed to be ready for automation and analytic monitoring of tissue function without manual handling - enabling effective high-throughput drug testing. The platform can be easily adapted for use with other tissue formats.

Tissue Systems Holding GmbH is a biotech company founded in 2012, which owns and commercializes technologies in the field of tissue engineering particularly in cardiology. The daughter company Myriamed GmbH (www.myriamed.com) is the operative arm and commercializes these technologies as a service provider for drug and toxicity screenings.

University Medical Center Göttingen (UMG) brings together the Medical Faculty and the University Clinic under one roof. It focuses on research on socially important diseases. These research areas are intended to provide a transfer from basic research to clinical practice.

The UMG is the only maximum care hospital in southern Lower Saxony and is involved in three clinical and research areas: neurosciences, cardiovascular diseases and oncology. Since 2003 UMG and University of Göttingen have been University of Göttingen public law foundation. The UMG is also the largest employer in the region in southern Lower Saxony.

MBM ScienceBridge GmbH is a fully owned technology transfer organization by the University of Göttingen and acts on behalf of nine research institutions in Lower Saxony as a technology transfer interface to companies around the world. The IP portfolio managed by MBM ScienceBridge covers innovation in the areas of Life Sciences, Chemistry, Physics, Agriculture, Forestry and Medical Technologies.

photo: Multi-well tissue plate (48-well format) for automated cardiotoxic or drug screening. In each well a fully functional heart muscle tissue ring has been produced around two flexible pins, which can be easily monitored by automated video analysis. Source: T. Meyer.

contact: www.sciencebridge.de, info@sciencebridge.de, +49-(0)551-30724151.

Stefan Weller | idw - Informationsdienst Wissenschaft
Further information:
http://www.universitaetsmedizin-goettingen.de/

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>