Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Breast cancer discovered in its preliminary stages in mammography screening is usually aggressive


In the biennial mammography screening programme, the most frequent diagnosis of breast cancer in its preliminary stages is, biologically, the most aggressive form. High-grade ductal carcinoma in situ holds the greatest risk of developing into a so-called invasive carcinoma. The tumour in question is malignant and grows into the surrounding tissue, and can spread into the lymphatic nodes and other organs.

In the latest screening programme carried out in North Rhine-Westphalia, data were evaluated pertaining to around 714,000 women who had regularly taken part in the programme up to three times, with a two-year interval between each screening.

Digital screening mammography with fine calcifications (arrow) which resulted in the diagnosis of an aggressive preliminary stage of breast cancer.

Breast cancer at a preliminary stage was discovered in 1,970 women, and in half of these cases it was present in its most aggressive form in the follow-up screening.

The results indicate that there might be far fewer overdiagnoses in mammography screening than has been discussed so far. Overdiagnoses are cases of breast cancer that have been discovered which would not have become apparent during the lifetime of a woman who had not undergone any screening.

The greatest probability of an overdiagnosis being made is ascribed to the “harmless” preliminary stages of breast cancer which can develop into invasive breast cancer only more than ten years later.

On the basis of a large quantity of data, the interdisciplinary team of researchers at the University of Münster has shown that most of the preliminary stages of breast cancer discovered in subsequent rounds of screening are aggressive and that their development is far more quickly than of the more harmless forms.

Therefore, as a percentage they increase in repeated screenings. This means, conversely, that it is above all women who regular take part in mammography screening who benefit in particular.

The reason is that if the preliminary stages of the breast cancer are aggressive, they are often discovered as a result of this form of early detection before they can develop into invasive, aggressive breast cancer.

Original paper:

Weigel S, Khil L, Hense HW, Decker T, Wellmann J, Heidrich J, Sommer A, Heidinger O, Heindel W.
Detection Rates of Ductal Carcinoma in Situ with Biennial Digital Mammography Screening: Radiologic Findings Support Pathologic Model of Tumor Progression.
Radiology. 2018 Feb; 286(2): 424-432 [Epub 2017 Nov 6]. Doi: 10.1148/radiol2017170673

Weitere Informationen:

PD Dr. med. Stefanie Weigel | idw - Informationsdienst Wissenschaft
Further information:

More articles from Health and Medicine:

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

nachricht Pain: Perception and motor impulses arise in the brain independently of one another
12.12.2018 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Latest News

UNLV study unlocks clues to how planets form

13.12.2018 | Physics and Astronomy

Live from the ocean research vessel Atlantis

13.12.2018 | Earth Sciences

Stanford researcher deciphers flows that help bacteria feed and organize biofilms

13.12.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>