5-hydroxymethylfurfural, a compound extracted from wine-processed Fructus corni, has a protective effect on hippocampal neurons damaged by H2O2. Prof. Mingyan Wang and team from Nanjing University of Chinese Medicine for the first time, used cytobiological and molecular biology methods to investigate the molecular mechanisms underlying the neuroprotective effects of 5-hydroxymethylfurfural on rat hippocampal neurons injured by oxidative stress.
Researchers found that 5-hydroxymethylfurfural could protect against H2O2-induced rat hippocampal neuron apoptosis by regulation of expression levels of the apoptosis-related genes p53, bcl-2, bax and caspases. This finding, published in the Neural Regeneration Research (Vol. 8, No. 28, 2013), provides theoretical evidence for the treatment of neurodegenerative disease with 5-hydroxymethylfurfural extracted from wine-processed Fructus corni and lays the foundations for clinical prevention and treatment of oxidative injury-related diseases in the brain.
Article: "5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis" by Hai Gu1, Zequn Jiang1, Mingyan Wang1, Haiying Jiang1, Fengming Zhao1, Xia Ding2, Baochang Cai1, Zhen Zhan1 (1 College of Basic Medical Sciences, Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu Province, China; 2 Department of Chemistry, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China)
Gu H, Jiang ZQ, Wang MY, Jiang HY, Zhao FM, Ding X, Cai BC, Zhan Z. 5-Hydroxymethylfurfural from wine-processed Fructus corni inhibits hippocampal neuron apoptosis. Neural Regen Res. 2013;8(28):2605-2614.
Meng Zhao | EurekAlert!
Opioids: no effect without side effect
21.01.2019 | Universitätsklinikum Jena
The cytoskeleton of neurons has been found to be involved in Alzheimer's disease
18.01.2019 | University of the Basque Country
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
16.01.2019 | Event News
14.01.2019 | Event News
12.12.2018 | Event News
21.01.2019 | Life Sciences
21.01.2019 | Physics and Astronomy
21.01.2019 | Life Sciences