The results of the study could help reduce malaria-associated mortality
There are more clinical phenotypes of severe malaria than those defined by the World Health Organization (WHO), according to a study led by ISGlobal, an institution supported by "la Caixa" Foundation. The results indicate that heart failure can be a pathogenic mechanism of disease, which has implications in the clinical management of these patients.
Despite the progress achieved over the last decades, malaria is estimated to have caused almost half a million deaths in 2016, mostly among children. The definition of severe malaria was established to identify those children at risk of dying, but in reality it is a complex and heterogeneous disease that not always responds to the recommended treatments.
The team led by Climent Casals-Pascual, researcher at ISGlobal and at Oxford University, applied a computational analysis based on networks in order to identify biologically relevant phenotypes apart from those currently defined by the WHO (cerebral malaria, respiratory distress, and severe malarial anaemia). For this, they performed a 'network-based clustering analysis' with data from almost 3,000 Gambian children hospitalized with malaria.
They found that the mortality was higher in those clusters with higher phenotypic heterogeneity. The analysis revealed four clusters of patients with both respiratory distress and severe anaemia, in which an increase in liver size was associated with higher mortality. By analysing plasma proteins of these patients, they showed that this is likely due to heart failure.
"Our results indicate that heart failure should be reconsidered as a pathogenic mechanism in severe malaria," explains Casals-Pascual, "and that therefore the standard clinical management may not be appropriate for these patients". This type of "systems approach" can be a very valuable tool to identify new phenotypes and mechanisms as well as therapeutic options for complex diseases", he adds.
Cominetti O, Smith D, Hoffman F, et al. Identification of a novel clinical phenotype of severe malaria using a network-based clustering approach. Scientific Reports. 2018. 8:12849. DOI:10.1038/s41598-018-31320-w
Adelaida Sarukhan | EurekAlert!
Novel anti-cancer nanomedicine for efficient chemotherapy
17.09.2019 | University of Helsinki
Researchers have identified areas of the retina that change in mild Alzheimer's disease
16.09.2019 | Universidad Complutense de Madrid
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.
At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.
Almost everyone is familiar with light strips for interior design. LED strips are available by the metre in DIY stores around the corner and are just as often...
Later during this century, around 2060, a paradigm shift in global energy consumption is expected: we will spend more energy for cooling than for heating....
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.
This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.
Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.
If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...
10.09.2019 | Event News
04.09.2019 | Event News
29.08.2019 | Event News
18.09.2019 | Innovative Products
18.09.2019 | Physics and Astronomy
18.09.2019 | Materials Sciences