A case report published in the journal American Journal of Transplantation presents a novel surgical technique that enables surgeons to remove tumors that are unresectable by the usual surgical techniques.
Led by Tomoaki Kato, MD, FACS, of Columbia University, surgeons removed tumors in 3 patients involving both the celiac artery and SMA using new surgical techniques never performed before, known as "ex vivo" surgery where the organs are removed to do surgery.
First, surgeons removed entire abdominal organs together with the tumor. The patient is "organless" during this period. The tumor was cut and blood vessels were reconstructed using synthetic vascular grafts. Surgeons then re-implanted the organs back into the patient's abdomen, connecting blood vessels and gastrointestinal tracts.
Surgery was successful, and all 3 patients are alive with no tumor recurrence to date after 2 to 4 years from the surgery.
"Our technique appears both feasible and effective in the proper clinical situation when performed by a multidisciplinary team experienced in multivisceral transplantation," Kato notes. "This technique can expand the role of transplant surgery in specific oncological problem, and more patients with 'inoperable' tumors can be operated."
Amy Molnar | EurekAlert!
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Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.
At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.
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Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.
This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.
Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.
If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...
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