"The results of this study show that radiologists can predict cardiovascular disease fairly well using incidental findings of calcifications of the aortic wall on CT, along with minimal patient information, such as age, gender and the reason for the CT," said the study's lead author, Martijn J. A. Gondrie, M.D., from the Julius Center for Health Sciences and Primary Care at the University Medical Center Utrecht in the Netherlands. "Ultimately, this easily executed extra risk stratification has the potential to reduce future heart attacks or other cardiovascular events."
Over the past 10 years, the use of chest CT has increased substantially, and CT image quality has dramatically improved. As a result, many more incidental findings occur. Incidental findings are unexpectedly detected imaging characteristics that are unrelated to the original clinical indication for the CT.
Dr. Gondrie's study is part of the Prognostic Value of Ancillary Information in Diagnostic Imaging (PROVIDI) project, which aims to investigate the relevance of unexpectedly detected imaging findings on chest CT.
"This is the first study to investigate whether incidental findings can predict future disease in a routine care setting," Dr. Gondrie said. "Incidental findings are obtained without additional radiation exposure or cost to the patient and may hold valuable clues as to the patient's overall health and their risk for future disease."
Dr. Gondrie and colleagues developed prediction models incorporating incidental aortic findings detected on chest CT. From a total of 6,975 patients who had undergone diagnostic, contrast-enhanced chest CT for non-cardiovascular indications, a representative sample of 817 patients, plus 347 patients who experienced a cardiovascular event during a mean follow-up period of 17 months, were included in the study. Scores were assigned for incidental aortic abnormalities found on CT, including calcifications, plaques, elongation and other irregularities. Other factors taken into account included the patient's age, gender, and CT indication.
While each aortic abnormality was highly predictive, the prediction model incorporating the sum score for aortic calcifications was most indicative of future cardiovascular events.
"PROVIDI is the first study of its scale and scope that seeks to investigate the potential of incidental findings to predict future disease and thus identify patients at risk," Dr. Gondrie said. "It generates the much-needed insights that allow more effective utilization of the increasing amount of diagnostic information, and it could potentially change the way radiologists contribute to the efficiency of daily patient care."
"Cardiovascular Disease: Prediction with Ancillary Aortic Findings on chest CT Scans in Routine Practice." Collaborating with Dr. Gondrie were Willem P. T. M. Mali, M.D., Ph.D., Peter C. Jacobs, M.D., Ph.D., Ay L. Oen, M.D., and Yolanda van der Graaf, M.D., Ph.D., for the PROVIDI Study Group.
Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology.rsna.org/)
RSNA is an association of more than 44,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. The Society is based in Oak Brook, Ill. (RSNA.org)
For patient-friendly information on chest CT, visit RadiologyInfo.org.
Linda Brooks | EurekAlert!
A 15-minute scan could help diagnose brain damage in newborns
15.11.2018 | Imperial College London
NIH scientists combine technologies to view the retina in unprecedented detail
14.11.2018 | NIH/National Eye Institute
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences