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Research towards improved cochlear implants - Computer model shows neuronal activation patterns in the inner ear


Cochlear implants restore hearing in deaf people to an amazingly high level. In order to optimize such implants, researchers at the Technical University of Munich (TUM) have developed a computer model which predicts the neuronal activation patterns that the implant creates in the auditory nerve fibers. As a starting point, the researchers used a high-resolution representation of the human inner ear.

People with normal hearing perceive sound by means of hair cells located in the cochlea, the fluid-filled hollow part of the inner ear. These hair cells convert sonic vibrations into auditory nerve impulses which are then passed on to the brain where they cause hearing sensations.

3D image of the human inner ear with an inserted cochlear implant electrode, reconstructed from a high-resolution computer tomography. The auditory nerve fibers are shown in purple.

Image: Siwei Bai / TUM

Prof. Dr. Werner Hemmert and Dr. Siwei Bai have developed a computer model which predicts the neuronal activation patterns that cochlea implants create in the auditory nerve.

Photo: Andereas Heddergott

For several decades it has now been possible to restore hearing in people with deafness or severe hearing loss at an amazingly high level with the help of cochlear implants.

The implants use an external microphone to capture sound information from the air and transfer it to implanted electrodes. These electrodes directly stimulate the auditory nerve fibers in the inner ear with electric impulses, so that the patient can perceive sound once again.

Imprecise auditory perception

The special structure of the inner ear makes hair cells at different locations in the cochlea sensitive to different pitches. We perceive the impulses transmitted by the docked nerves as tones with the respective corresponding pitch.

The electrodes of a cochlear implant are also positioned at various points along the cochlea. When sound of a particular pitch reaches the implant's microphone, a specific electrode emits electrical signals.

However, one electrode not only activates the nerve fibers in its immediate vicinity, but as current spreads widely in the salt-water filled inner ear, it also activates nerve fibers at more remote areas of the cochlea. As a result, cochlear-implant users cannot differentiate between impulses corresponding to electrode contacts located too close to each other. This limits the number of useful electrode contacts in actual implants.

Computer model shows signal spread

Understanding the best possible positioning of the electrode contacts requires knowledge of how the signals of the individual electrodes activate the nerve fibers. Researchers in the working group of Werner Hemmert, Professor for Bio-Inspired Information Processing at the Technical University of Munich (TUM), have come a major step closer to achieving this goal. They have developed a complex computer model that precisely calculates the spread of the electrical signals in the inner ear.

First, working together with colleagues at the university hospital TUM Klinikum rechts der Isar, the team used high-resolution computed tomography to create a three-dimensional representation of the bone containing the cochlea.

“The representation also showed the fine pores through which the auditory nerve fiber bundles pass,” explains Siwei Bai, post-doctoral researcher in Hemmert's research group and first author of the study. Using an algorithm developed by the group, the three-dimensional micro-structures of these pores could be used to reconstruct the paths of the individual nerve fibers, running from the cochlea through the bone all the way to the brain.

More complex than expected

“We were surprised at how unevenly the nerve fibers react to the implant's electrical signals: Some are very sensitive and are easily activated by almost all electrodes. Others are less sensitive and are mainly stimulated by the electrodes closest to them,” says Hemmert.

“This is a result of fine anatomical differences and the exact trajectories of the auditory nerve fibers.” Thus, it cannot be generally assumed that a given electrode will have a stronger effect on nerve fibers in its proximity than on more distant nerve fibers.

Up to now, researchers had constructed radial-symmetric models that predicted a uniform decay of the sensitivity of the auditory nerve fibers with distance to the electrode. The new findings however show how important it is to begin with a precise representation of the irregular bone and auditory nerve fibers.

Optimizing implants – Improving quality of life

In a next step, the researchers plan to incorporate the exact structure of the individual nerve fibers in their model. Then, they will be able to determine exactly where the electric pulses stimulate the nerve fibers and how the pulses spread along the fibers. “All these results will then be used in the development of new implants which will improve the quality of the stimulation, improving language understanding and ultimately also the patient's quality of life,” Hemmert concludes.

Wissenschaftliche Ansprechpartner:

Prof. Dr. Werner Hemmert
Technical University of Munich
Bio-Inspired Information Processing
Munich School of BioEngineering
Phone: +49 89 289 10853

Dr. Siwei Bai
Phone: +49 89 289 10842


Electrical Stimulation in the Human Cochlea: A Computational Study Based on High-Resolution Micro-CT Scans
Siwei Bai, Jörg Encke, Miguel Obando-Leitón, Robin Weiß, Friederike Schäfer, Jakob Eberharter, Frank Böhnke and Werner Hemmert
Frontiers in Neuroscience, 5 December 2019, Link:

Weitere Informationen: Profile of Prof. Werner Hemmert Bio-Inspired Information Processing at TUM Munich School of BioEngineering where Prof. Hemmert is conducting his research This release on the website of TUM

Dr. Ulrich Marsch | Technische Universität München

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