In an article in the latest issue of Molecular & Cellular Proteomics, Uppsala University researchers describe a technique that the journal regards as especially interesting.
Proteins build up the body’s cells and tissues, and our knowledge of the human genome also entails that today’s scientists are aware of all of the proteins that our body can produce. It is known that many morbid conditions can be linked to changes in proteins, so it is important to enhance our knowledge of what proteins bind to each other, how they work together, and how processes are impacted by various disturbances.
In 2006 Ola Söderberg and his colleagues at the Department of Genetics and Pathology devised a new technique, in situ PLA (in situ proximity ligation assay), that could detect communication between proteins in cells. These researchers have now refined the method and can now see how proteins undergo change inside a cell.
“The method provides a better potential to truly understand how proteins function in the cell and can show what is wrong with a sick cell, as in cancer, for instance. The refined method has the potential to revolutionize cancer diagnostics, so there has been a great deal of interest in the method from the research community,” says Ola Söderberg.
The technique is more sensitive and more reliable than other available techniques in molecular diagnostics, and it has already started to be sold by the Uppsala company Olink, so there are high hopes that it will soon be used in health care.
Anneli Waara | alfa
A 15-minute scan could help diagnose brain damage in newborns
15.11.2018 | Imperial College London
NIH scientists combine technologies to view the retina in unprecedented detail
14.11.2018 | NIH/National Eye Institute
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences