Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UF researchers find triggers in cells' transition from colitis to cancer

14.10.2009
University of Florida researchers have grown tumors in mice using cells from inflamed but noncancerous colon tissue taken from human patients, a finding that sheds new light on colon cancer and how it might be prevented.

Scientists observed that cancer stem cells taken from the gastrointestinal system in patients with a chronic digestive disease called ulcerative colitis will transform into cancerous tumors in mice.

The finding, now online and to be featured on the cover of the Thursday (Oct. 15) issue of Cancer Research, may help explain why patients with colitis have up to a 30-fold risk of developing colon cancer compared with people without the disease.

New understanding of the link between colitis and cancer could lead to diagnostic tests that would evaluate tissue taken from patients with colitis for signs of cancer stem cell development, thereby identifying patients who may be at greater risk for cancer.

"Ultimately it would be great if we could prevent colitis or treat colitis so it never gets to the cancerous stage," said UF colorectal surgeon Emina Huang, M.D., who is a member of the Program in Stem Cell Biology and Regenerative Medicine at UF's McKnight Brain Institute and the UF College of Medicine.

Although colonoscopy is very effective in screening and preventing colon cancer for most people, for patients with colitis no diagnostic tests work well because the inflamed tissue makes identification of precancerous changes difficult.

According to the Crohn's and Colitis Foundation of America, approximately 700,000 people have colitis in the United States. The National Cancer Institute estimates that cancer of the colon and rectum will claim the lives of about 50,000 people this year.

UF scientists gathered colitic tissue from humans and chemically screened it for colon cancer stem cells, also called tumor initiating cells. These cells were then isolated and monitored in mice to see if tumors would grow.

Huang said these findings shed light on that fact that it may not be just the cancer "seed" cell, but the "soil" – in this case inflamed colon tissue – that plays a role in the development of cancer.

"Is it the seed, is it the soil or is it their interaction?" she said. "We think probably both, but now we have a new way to look at it and a new method of attack."

B. Mark Evers, M.D., a professor and vice chair of surgery at the University of Kentucky College of Medicine, said the study emphasizes the emerging role of the surrounding inflammatory tumor microenvironment on tumor growth and subsequent metastasis.

"Dr. Huang and her group have identified a potentially important mechanism to explain why long-standing inflammation of the colon predisposes patients to the development of cancer," said Evers, who is director of the Lucille P. Markey Cancer Center in Lexington, Ky.

To further understand the role of the "seed" and "soil" interaction, UF researchers paired colon cancer stem cells with normal, colitic and cancerous human cells taken from the scaffolding layer of the large intestine. The cells were implanted into mice to analyze growth rates. The combination of tumor cells and normal scaffolding tissue cells grew at the slowest rate. Tumor cells paired with cancerous tissue grew at an intermediate rate, and tumor cells paired with the colitic tissue grew at the fastest rate.

Huang said they found heightened levels of two immune system hormones called interleukin-6 and interleukin-8 in the cells from the colitic and cancerous tissues, which had the faster growth rates.

When UF researchers decreased the expression of these hormones within the cells, the tumor growth drastically decreased. When the hormones returned, the tumors began to grow again.

"We don't understand the transition at the molecular level so we are trying to figure out what we can target to interfere, intervene or inhibit that transformation of the benign colitic cells," she said. "The thought is if we can create a therapy to decrease function of these hormones, we may be able to prevent or inhibit cancer growth."

Clinical trials looking at the role of one of these hormones in humans are under way in England, Huang said.

Jennifer Brindise | EurekAlert!
Further information:
http://www.ufl.edu

More articles from Life Sciences:

nachricht Brought to light – chromobodies reveal changes in endogenous protein concentration in living cells
21.09.2018 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen

nachricht A one-way street for salt
21.09.2018 | Julius-Maximilians-Universität Würzburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists present new observations to understand the phase transition in quantum chromodynamics

The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.

This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.

Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...

Im Focus: Patented nanostructure for solar cells: Rough optics, smooth surface

Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.

"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...

Im Focus: New soft coral species discovered in Panama

A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.

Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...

Im Focus: New devices based on rust could reduce excess heat in computers

Physicists explore long-distance information transmission in antiferromagnetic iron oxide

Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.

Im Focus: Finding Nemo's genes

An international team of researchers has mapped Nemo's genome

An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

"Boston calling": TU Berlin and the Weizenbaum Institute organize a conference in USA

21.09.2018 | Event News

One of the world’s most prominent strategic forums for global health held in Berlin in October 2018

03.09.2018 | Event News

4th Intelligent Materials - European Symposium on Intelligent Materials

27.08.2018 | Event News

 
Latest News

Three NASA missions return first-light data

24.09.2018 | Physics and Astronomy

Brown researchers teach computers to see optical illusions

24.09.2018 | Information Technology

Astrophysicists measure precise rotation pattern of sun-like stars for the first time

21.09.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>