Mitochondria in neurons are the powerhouses that generate energy to execute cellular functions and regulate neuronal survival under conditions of stress.
Collaborative research by Prof. Vidita Vaidya and Prof. Ullas Kolthur-Seetharam groups at TIFR, along with Dr. Ashok Vaidya, at Medical Research Centre, Kasturba Health Society, has demonstrated an unusual function for the neurotransmitter serotonin, in the generation of new mitochondria--a process called mitochondrial biogenesis--in neurons, accompanied by increase in cellular respiration and ATP, the energy currency of the cell.
These effects of serotonin involve the serotonin2A receptor and master regulators of mitochondrial biogenesis, SIRT1 and PGC-1α. Serotonin reduces toxic reactive oxygen species in neurons, boosts anti-oxidant enzymes and buffers neurons from the damaging effects of cellular stress.
This study (Fanibunda et al., 2019), appearing in the international journal PNAS, uncovers an unprecedented role for serotonin in energy production in neurons directly impacting how neurons handle stress.
Mitochondrial function in neurons is vital in determining how neurons cope with stress and the trajectory of aging.
This work provides exciting evidence that the neurotransmitter serotonin can directly influence neuronal powerplants, thus impacting the manner in which neurons grapple with stress.
This work identifies novel drug targets for treating mitochondrial dysfunction in neurons, with therapeutic potential for neurodegenerative and psychiatric disorders.
Vidita A. Vaidya | EurekAlert!
Uncovering hidden intelligence of collectives
24.09.2019 | Universität Konstanz
Crystal growth kinetics and its link to evolution. New findings about biomineralization in molluscan shells
24.09.2019 | Technische Universität Dresden
For applications such as light-emitting diodes or solar cells, organic materials are nowadays in the focus of research. These organic molecules could be a promising alternative to currently used semiconductors such as silicon or germanium and are used in OLED displays. A major problem is that in many organic semiconductors the flow of electricity is hampered by microscopic defects. Scientists around Dr. Gert-Jan Wetzelaer and Dr. Denis Andrienko of the Max-Planck-Institute for Polymer Research have now investigated how organic semiconductors can be designed such that the electric conduction is not influenced by these defects.
The basic principle of the first light bulb, invented by Thomas Edison in the 19th century, was quite simple: Electrons – negatively charged particles – flow...
How long the battery of your phone or computer lasts depends on how many lithium ions can be stored in the battery's negative electrode material. If the battery runs out of these ions, it can't generate an electrical current to run a device and ultimately fails.
Materials with a higher lithium ion storage capacity are either too heavy or the wrong shape to replace graphite, the electrode material currently used in...
To process information, photons must interact. However, these tiny packets of light want nothing to do with each other, each passing by without altering the...
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.
At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.
Almost everyone is familiar with light strips for interior design. LED strips are available by the metre in DIY stores around the corner and are just as often...
19.09.2019 | Event News
10.09.2019 | Event News
04.09.2019 | Event News
24.09.2019 | Life Sciences
24.09.2019 | Life Sciences
24.09.2019 | Materials Sciences