Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Serotonin boosts neuronal powerplants protecting against stress

10.05.2019

Mitochondria in neurons are the powerhouses that generate energy to execute cellular functions and regulate neuronal survival under conditions of stress.

Collaborative research by Prof. Vidita Vaidya and Prof. Ullas Kolthur-Seetharam groups at TIFR, along with Dr. Ashok Vaidya, at Medical Research Centre, Kasturba Health Society, has demonstrated an unusual function for the neurotransmitter serotonin, in the generation of new mitochondria--a process called mitochondrial biogenesis--in neurons, accompanied by increase in cellular respiration and ATP, the energy currency of the cell.


This is serotonin action on neuronal mitochondria.

Credit: Vidita A. Vaidya and Ullas Kolthur-Seetharam

These effects of serotonin involve the serotonin2A receptor and master regulators of mitochondrial biogenesis, SIRT1 and PGC-1α. Serotonin reduces toxic reactive oxygen species in neurons, boosts anti-oxidant enzymes and buffers neurons from the damaging effects of cellular stress.

This study (Fanibunda et al., 2019), appearing in the international journal PNAS, uncovers an unprecedented role for serotonin in energy production in neurons directly impacting how neurons handle stress.

Mitochondrial function in neurons is vital in determining how neurons cope with stress and the trajectory of aging.

This work provides exciting evidence that the neurotransmitter serotonin can directly influence neuronal powerplants, thus impacting the manner in which neurons grapple with stress.

This work identifies novel drug targets for treating mitochondrial dysfunction in neurons, with therapeutic potential for neurodegenerative and psychiatric disorders.

Media Contact

Vidita A. Vaidya
vvaidya@tifr.res.in
91-222-278-2806

http://www.tifr.res.in 

Vidita A. Vaidya | EurekAlert!
Further information:
http://dx.doi.org/10.1073/pnas.1821332116

More articles from Life Sciences:

nachricht How to generate a brain of correct size and composition
10.05.2019 | Institute of Science and Technology Austria

nachricht New type of highly sensitive vision discovered in deep-sea fish
10.05.2019 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers take a step towards light-based, brain-like computing chip

Researchers from the Universities of Münster (Germany), Oxford and Exeter (both UK) have succeeded in developing a piece of hardware which could pave the way for creating computers which resemble the human brain. The scientists produced a chip containing a network of artificial neurons that works with light and can imitate the behaviour of neurons and their synapses. The network is able to “learn” information and use this as a basis for computing and recognizing patterns. As the system functions solely with light and not with electrons, it can process data many times faster than traditional systems. The study is published in “Nature”.

A technology that functions like a brain? In these times of artificial intelligence, this no longer seems so far-fetched - for example, when a mobile phone can...

Im Focus: First demonstration of antimatter wave interferometry

An international collaboration with participation of the University of Bern has demonstrated for the first time in an interference experiment that antimatter particles also behave as waves besides having particle properties. This success paves the way to a new field of investigations of antimatter.

Matter waves constitute a crucial feature of quantum mechanics, where particles have wave properties in addition to particle characteristics. This...

Im Focus: Quantum sensor for photons

A photodetector converts light into an electrical signal, causing the light to be lost. Researchers led by Tracy Northup at the University of Innsbruck have now built a quantum sensor that can measure light particles non-destructively. It can be used to further investigate the quantum properties of light.

Physicist Tracy Northup is currently researching the development of quantum internet at the University of Innsbruck. The American citizen builds interfaces...

Im Focus: RadarGlass: Functional thin-film structures for integrated radar sensors

It is only an inconspicuous piece of paper, but it is an important milestone for autonomous driving: At the end of 2018 the three partners from the joint research project RadarGlass applied for a patent for an innovative radar system. The Fraunhofer Institute for Laser Technology ILT from Aachen, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP from Dresden and the Institute of High Frequency Technology IHF of RWTH Aachen University have developed a coating process chain that enables radar sensors to be integrated in car headlights. After almost two years in development they have manufactured a working prototype.

Completely autonomous vehicles pose an enormous challenge for sensor technology because, in principle, the supporting system must hear, see and feel better...

Im Focus: Novel method developed by HKBU scholars could help produce purer, safer drugs

Physics and Chemistry scholars from Hong Kong Baptist University (HKBU) have invented a new method which could speed up the drug discovery process and lead to the production of higher quality medicinal drugs which are purer and have no side effects. The technique, which is a world-first breakthrough, uses a specific nanomaterial layer to detect the target molecules in pharmaceuticals and pesticides in just five minutes.

The new HKBU invention can be applied to the drug discovery process, as well as the production and quality control stages of pharmaceutical manufacturing. It...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Serotonin boosts neuronal powerplants protecting against stress

10.05.2019 | Life Sciences

Copper oxide photocathodes: laser experiment reveals location of efficiency loss

10.05.2019 | Process Engineering

Hummingbird robot uses AI to soon go where drones can't

10.05.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>