At sea level, the strong C-F bond makes fluorocarbons thermally and chemically stable. As a result, fluorocarbons have been used in many commercial applications including refrigerants, pesticides and non-stick coatings. In the upper atmosphere, however, high-energy photons and highly reactive ozone molecules can break apart fluorocarbons, with the well-known consequence of a depleted ozone layer and increased ultraviolet radiation at ground level. A determined chemist can break down fluorocarbons at ground level with certain organometallic compounds, but the reactions take a long time at very high temperatures. Other known reagents are both highly toxic and inefficient, so chemists have been searching for an economical and environmentally friendly method to dispose of fluorocarbons.
Reasoning that the problem already may have been solved by nature, the NIST/Philip Morris team looked to an enzyme called fluoroacetate dehalogenase used by a South African bacterium, Burkholderia sp. The enzyme enables the bacterium to pull the fluoride ion out of sodium fluoroacetate (disrupting a poisonous compound) at room temperature and without problematic metal ions. Enzymes are giant molecules, evolved to survive and work in the complex environment of a living organism; they can be difficult and expensive to adapt to an industrial process. Instead, the research team applied basic quantum mechanical theory of electron structures in molecules, together with the example of a known molecule that binds to and extracts chlorine ions, to calculate the make-up and geometry of the critical "active site" in the enzyme that does the work. They then designed in software a large ring-shaped molecule to hold those components in just the right orientation to break the C-F bond in methyl fluoride, a simple fluorocarbon.
Researchers at the University of Texas now are synthesizing the new molecule to test its effectiveness. If it matches theoretical predictions, it will be the first example of a simple organic molecular system able to break C-F bonds without extreme temperature and pressure conditions, and a demonstration of a novel technique for designing man-made molecules that can mimic the extraordinary selectivity and chemical activity of natural enzymes. Notes lead researcher Carlos Gonzalez, "All of these useful things are in nature, you just have to find them and make them more efficient."
Michael Baum | EurekAlert!
Microscope measures muscle weakness
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Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
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On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
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16.11.2018 | Life Sciences