A schematic representation of the genomic events associated with breast cancer progression, including the occurrence of telomere crisis.
These confocal microscope images highlight regions of chromosomes in cells of a breast duct exhibiting hyperplasia (left) and one exhibiting carcinoma in situ (right).
Telomere crisis is an important early event in the development of breast cancer, and its occurrence can be identified with precision, according to recent findings by a team of scientists at the Department of Energy’s Lawrence Berkeley National Laboratory and the University of California at San Francisco. Their report is now available through advance online publication of Nature Genetics.
Joe Gray, director of Berkeley Lab’s Life Sciences Division and a professor of laboratory medicine and radiation oncology at UCSF, is one of the paper’s lead authors, with Koei Chin and Britt Marie Ljung of UCSF; Carlos Ortiz de Solorzano, Paul Yaswen, and Martha Stampfer of Berkeley Lab; and Stephen J. Lockett from the National Cancer Institute.
In the breast, cells in a milk-collecting duct occasionally proliferate excessively due to development of a regulatory defect. Gray and his colleagues postulate that this results in a lesion called "usual ductal hyperplasia."
Paul Preuss | EurekAlert!
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