A schematic representation of the genomic events associated with breast cancer progression, including the occurrence of telomere crisis.
These confocal microscope images highlight regions of chromosomes in cells of a breast duct exhibiting hyperplasia (left) and one exhibiting carcinoma in situ (right).
Telomere crisis is an important early event in the development of breast cancer, and its occurrence can be identified with precision, according to recent findings by a team of scientists at the Department of Energy’s Lawrence Berkeley National Laboratory and the University of California at San Francisco. Their report is now available through advance online publication of Nature Genetics.
Joe Gray, director of Berkeley Lab’s Life Sciences Division and a professor of laboratory medicine and radiation oncology at UCSF, is one of the paper’s lead authors, with Koei Chin and Britt Marie Ljung of UCSF; Carlos Ortiz de Solorzano, Paul Yaswen, and Martha Stampfer of Berkeley Lab; and Stephen J. Lockett from the National Cancer Institute.
In the breast, cells in a milk-collecting duct occasionally proliferate excessively due to development of a regulatory defect. Gray and his colleagues postulate that this results in a lesion called "usual ductal hyperplasia."
Paul Preuss | EurekAlert!
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
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20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology