The main role in new findings about neovessel formation is played by a protein called tissue factor. This factor turns out to have both a stimulatory function and an inhibitory function in the generation of blood vessels. Normally these two functions neutralize each other, but in diseases like retinopathy - where unwanted blood vessels grow into the retina - this balance is disturbed. The research team shows this in an article in the May issue of Nature Medicine.
Tissue factor is found in the cell walls of endothelial cells that line the lumenal side of blood vessels. The part of the tissue factor that faces the cell exterior sends signals, in combination with a certain so-called coagulation factor, to activate blood vessel cells to generate new vessel structures. The part of the tissue factor that resides on the inside of cells sends opposing signals that inhibit cell activation.
The group has unraveled these mechanisms by using several methods. For one thing, they have managed to generate transgenic mice that lack either the inhibitory mechanism, the stimulatory mechanism, or both. The results turned out accordingly: in mice without the inhibitory mechanism, for example, they have observed abnormally rapid growth of blood vessels in the retina and in tumors.
UNH researchers create a more effective hydrogel for healing wounds
21.11.2018 | University of New Hampshire
Removing toxic mercury from contaminated water
21.11.2018 | Chalmers University of Technology
Innsbruck quantum physicists have constructed a diode for magnetic fields and then tested it in the laboratory. The device, developed by the research groups led by the theorist Oriol Romero-Isart and the experimental physicist Gerhard Kirchmair, could open up a number of new applications.
Electric diodes are essential electronic components that conduct electricity in one direction but prevent conduction in the opposite one. They are found at the...
Max Planck researchers revel the nano-structure of molecular trains and the reason for smooth transport in cellular antennas.
Moving around, sensing the extracellular environment, and signaling to other cells are important for a cell to function properly. Responsible for those tasks...
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
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