Independent research groups have uncovered a new class of proteins, called the chaplins, that function like amyloid fibrils to allow reproductive growth in the bacterium Streptomyces coelicolor. Amyloid proteins are most commonly recognized for their role in Alzheimers disease, where they aggregate into insoluble, mesh-like plaques in the brains of Alzheimers patients. This finding reveals an unprecedented role for amyloid-like proteins in Gram-positive bacteria.
S. coelicolor is a soil-dwelling bacterium that, along with its relatives, produces the majority of naturally derived antibiotics (e.g., tetracycline and erythromycin), as well as many antitumor, antifungal, and immunosuppressant agents. Unlike most other prokaryotes, S. coelicolor has a complex life cycle, producing two different cell types depending upon environmental conditions: vegetative substrate hyphae that grow in moist soil, and aerial hyphae that grow in air and give rise to reproductive spores.
As published in the July 15th issue of Genes & Development, independent research carried out by Dr. Marie Elliot, Dr. Mark Buttner and colleagues at the John Innes Centre (UK) and Stanford University (USA), and by Dennis Claessen, Dr. Lubbert Dijkhuizen, Dr. Han Wösten and colleagues at the University of Groningen and the University of Utrecht (Netherlands), have identified the chaplin protein family as essential mediators of aerial S. coelicolor growth. The research in the Netherlands was funded by a grant of the National Programme EET (Economy, Ecology and Technology) to find biological alternatives for the environmentally harmful antifouling compounds used today on ships.
Heather Cosel | EurekAlert!
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In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".
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Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.
researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...
Microelectronics as a key technology enables numerous innovations in the field of intelligent medical technology. The Fraunhofer Institute for Biomedical Engineering IBMT coordinates the BMBF cooperative project "I-call" realizing the first electronic system for ultrasound-based, safe and interference-resistant data transmission between implants in the human body.
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Thomas Heine, Professor of Theoretical Chemistry at TU Dresden, together with his team, first predicted a topological 2D polymer in 2019. Only one year later, an international team led by Italian researchers was able to synthesize these materials and experimentally prove their topological properties. For the renowned journal Nature Materials, this was the occasion to invite Thomas Heine to a News and Views article, which was published this week. Under the title "Making 2D Topological Polymers a reality" Prof. Heine describes how his theory became a reality.
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Scientists took a leukocyte as the blueprint and developed a microrobot that has the size, shape and moving capabilities of a white blood cell. Simulating a blood vessel in a laboratory setting, they succeeded in magnetically navigating the ball-shaped microroller through this dynamic and dense environment. The drug-delivery vehicle withstood the simulated blood flow, pushing the developments in targeted drug delivery a step further: inside the body, there is no better access route to all tissues and organs than the circulatory system. A robot that could actually travel through this finely woven web would revolutionize the minimally-invasive treatment of illnesses.
A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny microrobot that resembles a white blood cell...
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