RUB-Researchers from the Chair for Biophysics have developed a new method for the detailed study of the interaction between pharmaceuticals and their target proteins.
The pharmaceutical industry has already taken notice of the new infrared spectroscopy technique; the method is supposed to be implemented to investigate pharmacological agent-protein interactions in the EU project K4DD, which is supported by various major European pharmaceutical companies. “We now have a tool in our hands with which we can research the dynamics of pharmacologically interesting proteins in atomic detail,” Prof. Dr. Klaus Gerwert said.
“We want to undertake a targeted screening of substance libraries to look for potential pharmacological agents.” PD Dr. Carsten Kötting added that “with our technique future pharmaceuticals can be more closely tailored to illness-causing proteins, which can noticeably reduce the negative side effects of these drugs.” They described the new method together with Dr. Jörn Güldenhaupt and Philipp Pinkerneil in the scientific journal “ChemPhysChem,” which dedicated its cover story to this topic.
Funding for the project came from the Protein Research Department at the RUB, from the state of NRW in the framework of the Center for Vibrational Microscopy (CVM) and from the SFB 642, “GTP and ATP Dependent Membrane Processes,” whose speaker is Prof. Gerwert.
Further InformationProf. Dr. Klaus Gerwert, Chair for Biophysics, Faculty for Biology and Biotechnology at the Ruhr-Universität, 44780 Bochum, Germany, Phone: +49/234/32-24461
email@example.comClick for more
Dr. Josef König | idw
How molecules teeter in a laser field
18.01.2019 | Forschungsverbund Berlin
Discovery of enhanced bone growth could lead to new treatments for osteoporosis
18.01.2019 | University of California - Los Angeles
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
16.01.2019 | Event News
14.01.2019 | Event News
12.12.2018 | Event News
18.01.2019 | Materials Sciences
18.01.2019 | Life Sciences
18.01.2019 | Health and Medicine