Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

James Briscoe awarded 2008 EMBO Gold Medal

10.07.2008
The European Molecular Biology Organization (EMBO) announced that James Briscoe of the Medical Research Council’s National Institute for Medical Research will receive the prestigious EMBO Gold Medal for 2008.

Briscoe receives the award in recognition of his discovery that cells integrate time of exposure and concentration of a morphogen to subsequently mount a graded response.

Awarded annually, the EMBO Gold Medal recognises the outstanding contributions of young researchers in the molecular life sciences. Widely regarded as the most prestigious award of its kind in Europe, the Gold Medal highlights the high standards of Europe’s best scientists.

“James Briscoe has revolutionized our understanding of the specification of cell identity in a given spatial setting,” said Hermann Bujard, EMBO Executive Director. “His work exemplifies how talented scientists are advancing the field of molecular biology.”

Four years at Columbia University in New York as a postdoc in Thomas Jessell’s lab laid the foundation for Briscoe’s career as a developmental biologist. James says he “learned” developmental biology from working alongside Jessell and a “great” postdoc in the lab at the time, Johan Ericson.

While at Columbia University, Briscoe began to unravel the control mechanisms of neuronal cell identity in the ventral neural tube – a research theme sustained in his own lab at NIMR since taking up a group leader position in 2000. Specifically, the Briscoe lab studies the central role of the morphogen Sonic Hedgehog (Shh) to specify the position and subtype identity of neurons in the ventral spinal cord.

“We want to understand how neurons - nerve cells – are arranged in the spinal cord,” explains the EMBO Gold Medal winner for audiences other than his peers. “Specifically we are looking at the molecular basis of how different neuronal cells are organized in a developing embryo as a result of signals received from an important molecule called Sonic Hedgehog, or Shh, that is secreted from a particular region in the spinal cord.”

Briscoe and his group discovered a novel mechanism that allows cells to integrate the time of exposure and the concentration of the morphogen Shh to subsequently mount a graded response. In other words, different concentrations of the morphogen activate a signal within the receiving cell for different periods of times. Cells in turn respond to different durations of the signal by activating different genes and therefore becoming different types of nerve cells.

“The discovery that concentration is effectively converted into time is a major shift in our understanding of how a graded signal acts to regulate genes,” stated David Wilkinson, Head of Genetics and Development at NIMR, in his nomination of Briscoe for the EMBO Gold Medal.

James Briscoe’s contribution to the understanding of how cell identity is specified in a given spatial setting has established a new paradigm that may also apply in many other contexts. In addition to Shh, a number of other secreted molecules – members of different protein families – have also been implicated in acting as morphogens to pattern other tissues. “It is possible that other morphogens could use a similar mechanism to control cells, for example early in embryo development during gastrulation,” explains the Gold Medal winner.

“James’s discoveries have revealed general principles that may apply to many other contexts in which graded signals and downstream transcription factors control cell identity,” confirmed David Wilkinson.

Robb Krumlauf, former Head of Division at NIMR who helped to recruit Briscoe to the institute, points out his outstanding qualities at the bench: “At NIMR James rapidly established an independent and creative line of research in his own group. His work is highly rigorous, hits the heart of a problem, and continues to be timely and of wide general interest.”

Jim Smith of the Gurdon Institute agrees with Krumlauf that Briscoe’s work “has been remarkably creative and imaginative while retaining characteristic levels of careful experimentation and scholarship.”

On hearing the news of the EMBO Gold Medal Briscoe referred to the success of his team of researchers: “I have been very fortunate working with very talented and smart people. They taught me a lot, supported me fantastically, and made many significant contributions.”

In 2000, James Briscoe was selected to benefit from the highly competitive EMBO Young Investigator Programme, then in its first year and now renowned for its scientific excellence.

James Briscoe will receive the EMBO Gold Medal and an award of 10,000 euro on
6 September 2008 at the EMBO Members Workshop, Frontiers of Molecular Biology, in Tampere, Finland.

Suzanne Beveridge | alfa
Further information:
http://www.embo.org
http://www.embo.org/about_embo/press/embo_goldmedal08.html

More articles from Awards Funding:

nachricht Decoding cell communication
13.06.2019 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht ESJET printing technology for large area active devices awarded
11.04.2019 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fraunhofer IDMT demonstrates its method for acoustic quality inspection at »Sensor+Test 2019« in Nürnberg

From June 25th to 27th 2019, the Fraunhofer Institute for Digital Media Technology IDMT in Ilmenau (Germany) will be presenting a new solution for acoustic quality inspection allowing contact-free, non-destructive testing of manufactured parts and components. The method which has reached Technology Readiness Level 6 already, is currently being successfully tested in practical use together with a number of industrial partners.

Reducing machine downtime, manufacturing defects, and excessive scrap

Im Focus: Successfully Tested in Praxis: Bidirectional Sensor Technology Optimizes Laser Material Deposition

The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.

Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

'Sneezing' plants contribute to disease proliferation

24.06.2019 | Agricultural and Forestry Science

Researchers find new mutation in the leptin gene

24.06.2019 | Life Sciences

Non-invasive view into the heart

24.06.2019 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>