Two Berlin research teams led by Marie-Laure Yaspo at the Max Planck Institute for Molecular Genetics and Hans Lehrach at Alacris Theranostics GmbH in Berlin are partners in the TREGeneration consortium. Their goal is to develop new strategies for the treatment of Graft versus Host Disease, a serious complication following bone marrow transplantation. A total of 6 million euros was awarded to the consortium to perform a 5-year research project comprising a set of five parallel clinical trials.
Transplantation of stem cells can save the life of patients suffering from leukemia or other blood diseases. Between 30 and 50% of patients undergoing stem cell transplantation suffer from graft versus host disease, a potentially serious condition that results from donor immune cells "attacking" patient tissues like skin, internal organs and mucosa. The TREGeneration project aims to test a cell-based therapeutic approach, expected to result in fewer side effects than the pharmacological strategies currently available.
The project is centered on five clinical trials conducted in parallel by five groups in different European countries. In each trial, patients will be treated with a particular blood cell population called regulatory T cells purified from blood of the original bone marrow donor. These cells have the capacity to suppress the tissue damage caused by T cells from the transplanted bone marrow. These early clinical trials (phase I/II) aim to identify the safe dose to be administered and also to generate preliminary efficacy data.
The task of the Berlin groups of Marie-Laure Yaspo at the Max Planck Institute for Molecular Genetics and Hans Lehrach from Alacris Theranostics GmbH is to characterize the “deep immune status” of patients and donors with a new technology developed by the two groups themselves.
Using next generation sequencing, the scientists will analyze the T cell receptor repertoires in the donor and patient samples at several times after treatment in order to track the fate of individual T cell clones and populations during the clinical trials. The results are expected to contribute to a better understanding of the immune suppressive effects of the regulatory T cell treatment on the patients.
The TREGeneration consortium is led by João Lacerda’s team at the Instituto de Medicina Molecular in Lisbon, Portugal, and comprises eight partners from five European countries. The clinical trials will be run independently by each center and are led by proejct participants: João Forjaz de Lacerda at the Hospital de Santa Maria in Lisbon; Matthias Edinger at the Universitätsklinik in Regensburg, Germany; Frédéric Baron at the Laboratory of Cell and Gene Therapy, Sart-Tilman in Liège, Belgium; and Mario Arpinati at the Department of Hematology “Seràgnoli”, University Hospital S.Orsola-Malpighi, Bologna, Italy.
The data generated by the different clinical trials will be integrated within the framework of the statistical analysis performed by Marta García-Fiñana’s team from the Department of Biostatistics, Faculty of Health & Life Sciences, University of Liverpool, UK. GABO:mi from Munich, Germany, is the project management partner.
The European Research Program Horizon 2020
The European Union regularly announces research programs in order to develop and strenghten the European Research and Innovation Area by funding cross-border research projects. Horizon 2020 is the biggest EU Research and Innovation program ever with nearly €80 billion of funding available over 7 years (2014 to 2020). By fostering international collaboration in research and innovation, Horizon 2020 addresses the huge social challenges like fighting diseases, securing enery requirements or adapting to climate changes. It will support scientists all over the world to collaborate and find solutions for problems of social and global interest.
Dr. Patricia Marquardt | Max-Planck-Institut für molekulare Genetik
Muscle Growth in the Computer: International Team Wants to Unravel the Formation of Myofibrils
13.06.2018 | Technische Universität Dresden
Innovation Award of the United Nations Environment Programme for PhD Student from ZMT
22.03.2018 | Leibniz-Zentrum für Marine Tropenforschung (ZMT)
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences