Early signs of Alzheimer’s detected in cerebrospinal fluid

Christian Haass and coworkers have detected early signs of Alzheimer’s in the cerebrospinal fluid. Source: LMU

Researchers at the Munich site of the German Center for Neurodegenerative Diseases (DZNE) and the hospital of the Ludwig Maximilian University (LMU) Munich have now found an early immune response in individuals with a genetic predisposition to Alzheimer‘s: their brain’s showed abnormal immune reactions as early as about seven years before the expected onset of dementia.

These results demonstrate that in cases of Alzheimer‘s, inflammatory processes in the brain evolve dynamically and are precursors of dementia.

These immune responses can be detected by means of a protein in the cerebrospinal fluid, offering physicians the possibility to trace the progression of the disease. The study results are published in the journal “Science Translational Medicine”.

Original Publication
„Early changes of CSF sTREM2 in Dominantly Inherited Alzheimer’s Disease follow markers of Amyloid Deposition and Neuronal Injury“, Marc Suárez-Calvet, Miguel Ángel Araque Caballero, Gernot Kleinberger, Randall J. Bateman, Anne M. Fagan, John C. Morris, Johannes Levin, Adrian Danek, Michael Ewers, Christian Haass, Science Translational Medicine, DOI: 10.1126/scitranslmed.aag1767

https://www.dzne.de/en/about-us/public-relations/news/2016/press-release-no-23.h… Complete press release

Media Contact

Dr. Marcus Neitzert idw - Informationsdienst Wissenschaft

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

“Segment-jumping” ridgecrest earthquakes explored

Seismologists use supercomputer to reveal complex dynamics of multi-fault earthquake systems. On the morning of July 4, 2019, a magnitude 6.4 earthquake struck the Searles Valley in California’s Mojave Desert,…

“Sustainable” condenser tumble dryers

… create hundreds of tonnes of waterborne microfiber pollution. A new study has revealed that drying laundry using a condenser tumble dryer leads to hundreds of tonnes of potentially harmful…

Not so biodegradable

New study finds bio-based plastic and plastic-blend textiles do not biodegrade in the ocean. First-of-its-kind experiment off Scripps Pier finds only natural fibers degrade in the marine environment; plastic fabrics…

Partners & Sponsors