Tumor suppressor activity of PTEN
Using transgenic mice specifically lacking the PTEN gene in endothelial cells, Dr. Akira Suzuki and colleagues demonstrate that PTEN is required for normal cardiovascular development and that its loss enhanced tumor angiogenesis.
To be published in the September 1 issue of G&D, this new data suggests that PTEN regulates vascular growth factor (VGF) signaling to modulate cardiovascular development and post-natal neovascularization. Loss of PTEN in murine endothelial cells results is dysregulated VGF signaling, enhanced angiogenesis, and accelerated tumor growth.
Their results suggest that an individual who inherits a mutated PTEN allele, such as Cowden disease patient, is not only at risk for additional tumorigenic mutations, but may also experience accelerated growth of tumors due to enhanced angiogenesis. Moreover, the PTEN/PI3K pathway in endothelial cells is an attractive therapeutic target for the treatment of various malignancies.
Media Contact
More Information:
http://www.cshl.eduAll latest news from the category: Life Sciences and Chemistry
Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Newest articles
Detector for continuously monitoring toxic gases
The material could be made as a thin coating to analyze air quality in industrial or home settings over time. Most systems used to detect toxic gases in industrial or…
On the way for an active agent against hepatitis E
In order to infect an organ, viruses need the help of the host cells. “An effective approach is therefore to identify targets in the host that can be manipulated by…
A second chance for new antibiotic agent
Significant attempts 20 years ago… The study focused on the protein peptide deformylase (PDF). Involved in protein maturation processes in cells, PDF is essential for the survival of bacteria. However,…
