HIV virus hides in the brain

We now have effective anti-HIV drugs that can stop the immune system from being compromised and prevent AIDS. Although these drugs effectively prevent the virus from multiplying, the HIV virus also infects the brain and can cause damage if the infection is not treated.

“Antiviral treatment in the brain is complicated by a number of factors, partly because it is surrounded by a protective barrier that affects how well medicines get in,” says Arvid Edén, doctor and researcher at the Institute of Biomedicine at the Sahlgrenska Academy. “This means that the brain can act as a reservoir where treatment of the virus may be less effective.”

The thesis includes a study of 15 patients who had been effectively medicated for several years. 60% of them showed signs of inflammation in their spinal fluid, albeit at lower levels than without treatment.

“In another study of around 70 patients who had also received anti-HIV drugs, we found HIV in the spinal fluid of around 10% of the patients, even though the virus was not measurable in the blood, which is a significantly higher proportion than previously realised,” explains Edén.

The results of both studies would suggest that current HIV treatment cannot entirely suppress the effects of the virus in the brain, although it is not clear whether the residual inflammation or small quantities of virus in the spinal fluid in some of the patients entail a risk of future complications.

“In my opinion, we need to take into account the effects in the brain when developing new drugs and treatment strategies for HIV infection,” says Edén.

HIV
HIV, human immunodeficiency virus, belongs to the retrovirus family and takes two forms, HIV-1 and HIV-2, which can be transmitted through blood, semen and other secretions and bodily fluids. In the acute phase, patients suffer from fever, swollen lymph glands and rashes. These symptoms do recede, but AIDS develops after a long period of infection. Attempts to produce an HIV vaccine have been ongoing since the 1980s, but have yet to be successful.
For more information please contact:
Registered doctor Arvid Edén, mobile: +46 709 185 923, e-mail: arvid.eden@vgregion.se
Doctoral thesis for the degree of PhD (medicine) at the Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy.

Title of thesis: HIV Persistence and Viral Reservoirs