Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research links damaged organs to change in biochemical wave patterns

17.11.2010
By examining the distinct wave patterns formed from complex biochemical reactions within the human body, diseased organs may be more effectively identified, says Zhengdong Cheng, associate professor in the Artie McFerrin Department of Chemical Engineering at Texas A&M University, who has developed a model that simulates how these wave patterns are generated.

His findings, which appear in the October issue of the journal "Physical Review E," detail Cheng's work with a system designed to model cells in a biochemical environment, similar to what occurs inside the human body.

His system utilizes two types of resin beads to represent cells. Those beads loaded with a catalyst are referred to as active and represent living cells. Those beads that are not loaded with a catalyst are referred to as inactive and represent diseased or dead cells.

In contrast to previous experiments that have only focused on the effects of active beads, Cheng's system is the first to examine the effects of inactive beads, particularly the effects of significant increases in the inactive bead population within a system.

Because the beads within the sample represent cells, the increase in inactive beads, Cheng explains, simulates a higher percentage of dead or diseased cells within an organ, such as the heart.

What Cheng found is that as the population of inactive beads increases, the resulting wave patterns transform from target-shaped to spiral-shaped. The inference, Cheng notes, is that as tissue of an organ becomes more diseased and greater numbers of cells die, the biochemical reactions involving that organ will produce spiral wavelets instead of target wavelets.

This corresponds, Cheng notes, to observations made with electrocardiograms that reveal a change from pane-wave to spiral wavelets accompanying the procession from normal sinus rhythm to ventricular fibrillation, a cause of cardiac arrest.

Recognizing these wave patterns and what they represent, Cheng says, may lead to a better and more timely understanding of the structure of a diseased organ. This knowledge, he adds, could help determine whether an organ is becoming diseased as well as the extent of damage to an organ once it is diseased.

"For example, fibrotic nonexcitable 'dead' tissue normally presents as a small percentage of normal heart tissue," Cheng says. "As a result of aging, after a heart attack, or in the case of cardiac myopathies, the percentage of fibrotic tissue increases dramatically, up to 30 or 40 percent.

"In a scenario such as this, given our findings, we would expect to see more spiral-shaped wavelets when examining an organ that has incurred structural damage. A further increase in spiral wavelets could potentially signal an even greater percentage of structural damage to the heart," Cheng says.

Contact: Zhengdong Cheng at (979) 845-3413 or via email: cheng@chemail.tamu.edu or Ryan A. Garcia (979) 845-9237 or via email: ryan.garcia99@tamu.edu

Ryan A. Garcia | EurekAlert!
Further information:
http://www.tamu.edu

More articles from Physics and Astronomy:

nachricht A better way to weigh millions of solitary stars
15.12.2017 | Vanderbilt University

nachricht A chip for environmental and health monitoring
15.12.2017 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>