His findings, which appear in the October issue of the journal "Physical Review E," detail Cheng's work with a system designed to model cells in a biochemical environment, similar to what occurs inside the human body.
His system utilizes two types of resin beads to represent cells. Those beads loaded with a catalyst are referred to as active and represent living cells. Those beads that are not loaded with a catalyst are referred to as inactive and represent diseased or dead cells.
In contrast to previous experiments that have only focused on the effects of active beads, Cheng's system is the first to examine the effects of inactive beads, particularly the effects of significant increases in the inactive bead population within a system.
Because the beads within the sample represent cells, the increase in inactive beads, Cheng explains, simulates a higher percentage of dead or diseased cells within an organ, such as the heart.
What Cheng found is that as the population of inactive beads increases, the resulting wave patterns transform from target-shaped to spiral-shaped. The inference, Cheng notes, is that as tissue of an organ becomes more diseased and greater numbers of cells die, the biochemical reactions involving that organ will produce spiral wavelets instead of target wavelets.
This corresponds, Cheng notes, to observations made with electrocardiograms that reveal a change from pane-wave to spiral wavelets accompanying the procession from normal sinus rhythm to ventricular fibrillation, a cause of cardiac arrest.
Recognizing these wave patterns and what they represent, Cheng says, may lead to a better and more timely understanding of the structure of a diseased organ. This knowledge, he adds, could help determine whether an organ is becoming diseased as well as the extent of damage to an organ once it is diseased.
"For example, fibrotic nonexcitable 'dead' tissue normally presents as a small percentage of normal heart tissue," Cheng says. "As a result of aging, after a heart attack, or in the case of cardiac myopathies, the percentage of fibrotic tissue increases dramatically, up to 30 or 40 percent.
"In a scenario such as this, given our findings, we would expect to see more spiral-shaped wavelets when examining an organ that has incurred structural damage. A further increase in spiral wavelets could potentially signal an even greater percentage of structural damage to the heart," Cheng says.
Contact: Zhengdong Cheng at (979) 845-3413 or via email: firstname.lastname@example.org or Ryan A. Garcia (979) 845-9237 or via email: email@example.com
Ryan A. Garcia | EurekAlert!
Neutron star merger directly observed for the first time
17.10.2017 | University of Maryland
Breaking: the first light from two neutron stars merging
17.10.2017 | American Association for the Advancement of Science
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
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