Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

JLab, College of W&M researchers study radiation blockers

22.04.2005


JLab, College of W&M researchers study radiation blockers while conducting nuclear imaging of Iodine uptake in mouse tissues



Scientists have found that a dose five times higher than the FDA-recommended dosage of potassium iodide in the event of a nuclear accident is needed to protect small animals effectively from radioactive iodide in medical imaging procedures. The long-term animal nuclear imaging project is being conducted by a collaboration of biology and physics researchers from the Department of Energy’s Jefferson Lab and The College of William & Mary (CWM).

The research was conducted at the CWM with a Jefferson Lab and CWM-built medical imaging system to perform investigational studies of mice. Bob Welsh, a JLab/CWM jointly appointed professor, is one researcher working on the project. The research demonstrates that scientists can learn about how the body uses certain substances of interest - such as insulin, the fat-regulating protein leptin and a wide range of other biological compounds - by tracking how these substances move through the body of a mouse.


"The way we follow those substances is to attach to them a radioactive isotope of iodine, Iodine-125. Iodine-125 emits a low-energy gamma ray," Welsh says, "It’s not a tremendous amount of energy, but it’s easy to track with these very precise detectors that have been designed and built by the Jefferson Lab Detector Group."

The thyroid needs iodine to regulate metabolism and is unable to distinguish between regular dietary iodine and ingested radioactive iodine. So the researchers weren’t surprised when, in the course of the project, they noticed that the mice subjects’ thyroids always absorbed a significant amount of radioactive iodine. In addition to being potentially bad for the mouse, the thyroid’s absorption of radioactive iodine made the images difficult to interpret and could provide false-positive readings or possibly obscure substantial iodine uptake in nearby tissues.

The team decided to test what would happen if they gave the mice potassium iodide, the FDA-recommended drug for blocking radioactive iodine absorption by the thyroid in the event of a nuclear accident, before exposing the mice to a form of radioiodine used in imaging studies. CWM undergraduate William Hammond, who will be presenting the team’s findings at the American Physical Society (APS) April Meeting, Session E12.0004, participated in this phase of the research for his senior thesis project.

The researchers started with the potassium iodide dose that’s recommended for humans in the event of a nuclear incident, 130 mg (milligrams), and scaled that down to the mass of the mouse. They administered a liquid form of the drug to mice, injected the radioiodine for imaging an hour later, and then imaged the mouse.

"What we noticed was this: the dose that was exactly the scaled human dose did not completely block the uptake of radioiodine. But when we tried three times, five times, ten times the scaled human dose, we obtained results that indicate that ten times the human dose blocks 1.5-2 times better, though five times is just about as good as ten times," Welsh says.

The researchers recognized that the extra benefit gained by the largest potassium iodide dose administered could in some cases be outweighed by potential side effects. To protect their mice in future imaging studies, they’re planning to use the potassium iodide dose that’s five times the scaled-down human dose.

As for larger implications, the study should not simply be scaled-up and applied to humans. "It could say that a mouse’s metabolism is so different from a human’s that you can’t just scale the human dose down for mice. But when it comes to small animals, I think the results should be taken into consideration," Welsh notes.

This research was made possible by a collaboration of Jefferson Lab and College of William researchers, including CWM physicists Robert Welsh, Julie Cella, Coleen McLoughlin, Kevin Smith and William Hammond; CWM biologists Eric Bradley and Margaret Saha; CWM applied science graduate student Jianguo Qian; and Jefferson Lab Detector Group scientists Stan Majewski, Vladimir Popov, Mark Smith and Drew Weisenberger.

Kandice Carter | EurekAlert!
Further information:
http://www.jlab.org

More articles from Physics and Astronomy:

nachricht Significantly more productivity in USP lasers
06.12.2016 | Fraunhofer-Institut für Lasertechnik ILT

nachricht Shape matters when light meets atom
05.12.2016 | Centre for Quantum Technologies at the National University of Singapore

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Simple processing technique could cut cost of organic PV and wearable electronics

06.12.2016 | Materials Sciences

3-D printed kidney phantoms aid nuclear medicine dosing calibration

06.12.2016 | Medical Engineering

Robot on demand: Mobile machining of aircraft components with high precision

06.12.2016 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>