Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nano bubble gum for enhancing drug delivery in gut

10.11.2009
Of the many characteristic traits a drug can have, one of the most desirable is the ability for a drug to be swallowed and absorbed into the bloodstream through the gut.

Some drugs, like over-the-counter aspirin, lend themselves to this mode of delivery and are trivial to take. They can be pressed into a pill and swallowed. Other drugs cannot be swallowed and must be administered instead through more complicated routes. Insulin, for instance, must be injected.

The reason why insulin and many other drugs cannot be swallowed is that they cannot survive the trip through the digestive tract -- wherein they are first plunged into the acid bath of the stomach and then passed into the intestines, which are filled with enzymes designed to break down molecules like insulin. Aspirin does fine in the gut because its active ingredient is a small chemical that doesn't get broken down. But insulin is quickly degraded.

Tejal A. Desai (University of California, San Francisco) is looking at ways to enhance the "oral availability" of drugs by designing new delivery devices that will help their absorption in the gut, which she will present on November 12 at a meeting of the scientific society AVS in San Jose. Working with a Bay-area biotechnology company, she is making devices that are sort of like spiny beads filled with drugs. The spines on these beads are silicon nanowires designed to form an adhesive interface with the tiny, hair-like cilia that cover the cells lining the gut. They are designed to stick like burrs to the cells lining the gut and slowly release their drugs there. Localized in one spot, the drugs have a better chance of diffusing into the bloodstream.

Desai is currently fine-tuning the geometry of the nanowires in order to optimize their adhesion. Her laboratory has done a number of toxicity studies with the beads, and their plan next is to look at how effectively they can deliver proteins, peptides, and other macromolecules that are not usually taken orally.

One of the advantages of this approach, Desai says, is that it may be applicable for delivering drugs to other part of the body as well, such as mucosal tissues like the insides of the nose, lungs, or vagina, where the surface cells are also coated with such cilia.

The talk "Micro and Nanostructured Interfaces for Therapeutic Delivery" is at 11:20 a.m. on Thursday, November 12, 2009. Abstract: http://www.avssymposium.org/Open/SearchPapers.aspx?PaperNumber=TF-ThM-11

INFORMATION FOR JOURNALISTS

The AVS 56th International Symposium & Exhibition lasts from November 8-13, 2009 in San Jose, CA. All meeting information, including directions to the San Jose Convention Center is at: http://www2.avs.org/symposium/

Staff reporters and freelance journalists working on assignment for major media outlets are invited to attend the conference free of charge. Journalist registration instructions can be found at: http://www.avs.org/pdf/pressinvite.pdf

USEFUL LINKS

Online press room: http://www.avs.org/inside.press.aspx

Searchable abstracts: http://www.avssymposium.org/Open/SearchPapers.aspx

Full meeting program: http://www.avssymposium.org/Overview.aspx

Main meeting page: http://www2.avs.org/symposium/AVS56/pages/info.html

ONSITE MEETING PRESS ROOM

The AVS press room will be located in Concourse 1 of the San Jose Convention Center. Press room hours are Monday-Thursday, 8:00-5:00 pm. The phone number there is 408-271-6100. Press Kits containing company product announcements and other news will be available on CD-ROM in the press room.

ABOUT AVS

As a professional membership organization, AVS fosters networking within the materials, processing, and interfaces community at various local, national or international meetings and exhibits throughout the year. AVS publishes four journals, honors and recognizes members through its prestigious awards program, offers training and other technical resources, as well as career services.

Jason Bardi | EurekAlert!
Further information:
http://www.aip.org

More articles from Physics and Astronomy:

nachricht Tracing aromatic molecules in the early universe
23.03.2017 | University of California - Riverside

nachricht New study maps space dust in 3-D
23.03.2017 | DOE/Lawrence Berkeley National Laboratory

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>