Experiments show that infected red blood cells are stiffer and stickier than normal ones -- in the later stages of the disease, up to 10 times stiffer. They also tend to adhere to the endothelial cells lining the vasculature, affecting the normal blood flow. This explains some of the common symptoms of malaria, such as anemia and joint pain.
Sticking to the walls of blood vessels is a survival mechanism for the parasite. In order to develop completely, it needs several days inside a red blood cell. Even though parasitized cells are nearly invisible for the immune system, they may be destroyed in the spleen while circulating freely in the bloodstream.
Doctoral student Dmitry Fedosov and Brown University professor George Karniadakis are studying how malaria infections affect the physical properties of red blood cells, and alter normal blood flow circulation. In particular, they examine an increase in blood flow resistance, and dynamics of infected cells in the bloodstream.
They also monitor the mechanical properties of infected red blood cells by measuring membrane temperature fluctuations, and through the response of a "microbead" that is attached to the cell and twisted. The measured properties are then used in modeling the flow of red blood cells in people infected with malaria. They also collaborate with the group of professor Subra Suresh at MIT, who obtain experimental measurements of the properties and the flow of healthy and infected cells.
"Our model predicts the dynamics of malaria-infected RBCs in the bloodstream, which anticipates the possible course of the disease," says Fedosov.
Recently they found that temperature fluctuations of infected red blood cell membranes measured in experiments are not directly correlated with the reported cell properties, hence suggesting significant influence of metabolic processes. They measured an increase in resistance to blood flow in the capillaries and small arterioles during the course of malaria and found that parasitized red blood cells have a “flipping” motion at the vessel wall that appears to be due to stiffness of the infected cells. The developed models will aid to make realistic predictions of the possible course of the disease, and enhance current malaria treatments.
Abstract: http://meetings.aps.org/Meeting/DFD09/Event/111038MORE MEETING INFORMATION
Currently, the Division of Fluid Dynamics Virtual Press Room contains information related to the 2008 meeting. In mid-November, the Virtual Press Room will be updated for this year's meeting, and another news release will be sent out at that time.ONSITE WORKSPACE FOR REPORTERS
This year, selected entries from the 27th Annual Gallery of Fluid Motion will be hosted as part of the Fluid Dynamics Virtual Press Room. In mid-November, when the Virtual Press Room is launched, another announcement will be sent out.ABOUT THE APS DIVISION OF FLUID DYNAMICS
NASA laser communications to provide Orion faster connections
30.03.2017 | NASA/Goddard Space Flight Center
Pinball at the atomic level
30.03.2017 | Max-Planck-Institut für Struktur und Dynamik der Materie
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
30.03.2017 | Physics and Astronomy
30.03.2017 | Studies and Analyses
30.03.2017 | Life Sciences