Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A new paradigm for nanoscale resolution MRI has been experimentally achieved

30.09.2013
A team from the University of Illinois at Urbana-Champaign and Northwestern University has devised a novel nuclear magnetic resonance imaging (MRI) technique that delivers a roughly 10­nanometer spatial resolution.

This represents a significant advance in MRI sensitivity—modern MRI techniques commonly used in medical imaging yield spatial resolutions on the millimeter length scale, with the highest-resolution experimental instruments giving spatial resolution of a few micrometers.


Illustration of the experimental setup shows the two unique components of the teams novel MRI technique that was successful in producing a 2D MRI image with spatial resolution on the nanoscale.

“This is a very promising experimental result,” said U. of I. physicist Raffi Budakian, who led the research effort. “Our approach brings MRI one step closer in its eventual progress toward atomic-scale imaging.”

MRI is used widely in clinical practice to distinguish pathologic tissue from normal tissue. It is noninvasive and harmless to the patient, using strong magnetic fields and non-ionizing electromagnetic fields in the radio frequency range, unlike CT scans and tradiational X-rays, which both use more harmful ionizing radiation.

MRI uses static and time-dependent magnetic fields to detect the collective response of large ensembles of nuclear spins from molecules localized within millimeter-scale volumes in the body. Increasing the detection resolution from the millimeter to nanometer range would be a technological dream come true.

The team’s breakthrough—the new technique introduces two unique components to overcome obstacles to applying classic pulsed magnetic resonance techniques in nanoscale systems. First, a novel protocol for spin manipulation applies periodic radio-frequency magnetic field pulses to encode temporal correlations in the statistical polarization of nuclear spins in the sample. Second, a nanoscale metal constriction focuses current, generating intense magnetic field-pulses.

In their proof-of-principal demonstration, the team used an ultrasensitive magnetic resonance sensor based on a silicon nanowire oscillator to reconstruct a two-dimensional projection image of the proton density in a polystyrene sample at nanoscale spatial resolution.

“We expect this new technique to become a paradigm for nanoscale magnetic-resonance imaging and spectroscopy into the future,” added Budakian. “It is compatible with and can be incorporated into existing conventional MRI technologies.”

The team’s paper, “Nanoscale Fourier-Transform Magnetic Resonance Imaging,” is published in Physical Review X, v. 3, issue 3, 031016.

Contact: Raffi Budakian, Department of Physics, University of Illinois at Urbana-Champaign, 217/333-3065.

Siv Schwink, Department of Physics, 217/552-5671.

Raffi Budakian | EurekAlert!
Further information:
http://www.illinois.edu

More articles from Physics and Astronomy:

nachricht Comet or asteroid? Hubble discovers that a unique object is a binary
21.09.2017 | NASA/Goddard Space Flight Center

nachricht First users at European XFEL
21.09.2017 | European XFEL GmbH

All articles from Physics and Astronomy >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Comet or asteroid? Hubble discovers that a unique object is a binary

21.09.2017 | Physics and Astronomy

Cnidarians remotely control bacteria

21.09.2017 | Life Sciences

Monitoring the heart's mitochondria to predict cardiac arrest?

21.09.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>