Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vaccine against Chlamydia not far away

16.11.2009
When a woman becomes infected with Chlamydia, the first white blood cells that arrive at the scene to fight the infection are not the most effective. This is shown by a thesis from the Sahlgrenska Academy.

This discovery could pave the way for the relatively rapid development of a vaccine against Chlamydia.

"Now that we know how the body defends itself against the Chlamydia bacteria, we can develop a vaccine that optimises that defence. We have a basic understanding of how the vaccine could work, but some work remains to be done. We believe that it will take a few years before the vaccine becomes a reality," says researcher Ellen Marks, the author of the thesis.

The body defends itself against infections with a type of white cell called the T lymphocyte. When these blood cells take on the bacteria, they trigger an inflammation that can damage tissue, so there are also other similar blood cells whose main task is to reduce the inflammation and protect tissue. Ellen Marks and her colleagues are the first research team to discover that these anti-inflammatory forces predominate in the lower parts of the female genital tract, mainly mediated by a hormone called IL-10, which is highly protective against tissue damage.

"The result is that the T lymphocytes that could fight Chlamydia are not concentrated in the lower vagina, and the infection can move up towards the womb and fallopian tubes relatively unhindered," says Ellen Marks.

The research team already has a concept of how a vaccine based on this new understanding could work, and they have also tested it on mice.

"The method of administration is an important remaining issue. Previous research has shown that injections don't work, and so the vaccine will probably need to be given either as a nasal spray or in the form of a cream applied into the vagina," says Ellen Marks.

This research is being done at MIVAC (the Mucosal Immunology and Vaccine Center) - the Sahlgrenska Academy's strategic research centre. Researchers at the centre are developing novel methods of treating diseases that affect our mucous membranes.

FACTS ABOUT CHLAMYDIA
The incidence of Chlamydia infection in Sweden has increased since the mid-nineties, especially in people under the age of 24. Last year, over 40 000 new cases were reported to the Swedish Institute for Infectious Disease Control. The disease is caused by the bacterium Chlamydia trachomatis, which is transmitted by unprotected sexual contact. Many don't realise that they have been infected, because Chlamydia infection often has no symptoms at all. Without effective antibiotic treatment the infection can become chronic and may even lead to infertility.
For further information, please contact:
Ellen Marks, tel. +46 (0)31-786 63 02 or +46 (0)73-710 46 24, ellen.marks@immuno.ge.se
Supervisor:-ma
Professor Nils Lycke, tel. +46 (0)31-786 63 21, nils.lycke@microbio.gu.se
Thesis for the degree of Doctor of Medical Science at the Department of Microbiology and Immunology, Institute of Biomedicine, the Sahlgrenska Academy.

Title of thesis: Genital tract CD4+ T cells for vaccination and protection against Chlamydia trachomatis

The thesis has been defended.

You can read the complete thesis here: http://hdl.handle.net/2077/21075

Helena Aaberg | idw
Further information:
http://hdl.handle.net/2077/21075
http://www.sahlgrenska.gu.se/english/

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>