Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UH researchers explore treatments for breast and colon cancers

23.08.2011
2 studies on estrogen hormones published in Molecular Endocrinology

University of Houston (UH) researchers have their sights set on developing possible treatments for breast and colon cancer.

In two separate, yet related, studies published in the June and August issues of the journal Molecular Endocrinology, professor Cecilia Williams and her team at the Center for Nuclear Receptors and Cell Signaling (CNRCS) explored the role of estrogen hormones in potentially treating and preventing these cancers. More specifically, Williams examined regulatory molecules called estrogen receptors (ER), which are the tools that allow estrogen and related molecules to act in the cell.

Although estrogen is a female hormone, both men and women have receptors that are activated by estrogen. There are two types of estrogen receptors, ERalpha and ERbeta. ERalpha activity is associated with inducing breast cancer in women, whereas ERbeta is hypothesized to help prevent colon cancer.

In the first study, featured on the June cover of the journal Molecular Endocrinology, Williams and her team focused on the impact of ERbeta on colorectal cancer cells in cultures, called cell lines, to see how estrogen hormones could be used to prevent colon cancer. For each cell line, the researchers introduced this estrogen receptor to allow them to study its activity in the colon cancer cells. They found an association between the expression of ERbeta and tumor-fighting characteristics of the cells and identified the presence of several proteins involved in the protective interactions.

"Through our research, we found that the presence of estrogen receptor beta not only slowed the growth of colorectal cancer cells, but they also helped to protect against further development of the cancer," Williams said. "Our work demonstrates the potential of novel hormone compounds that activate this estrogen receptor to become possible new colon cancer preventive treatments."

In the second study, the team worked with the other estrogen receptor, ERalpha, to learn more about the mechanism by which estrogen induces growth of breast cancer tumor cells. The team identified the gene KCNK5, a potassium channel regulator found in tissues that controls a wide variety of cell functions, as a key gene involved in this growth. They showed that KCNK5 was stimulated by the activation of the estrogen receptors in breast cancer cell lines and is required for tumor cell growth. With this new knowledge, the researchers confirmed the potential of KCNK5 as a target for breast cancer therapeutics.

"Building on our colon cancer research reported in the June issue, we examined the influence of estrogen on gene expression as a way of targeting and treating breast cancer tumor cells," Williams said. "The results of our research will open new opportunities for treating cancer with novel compounds, such as hormone therapy, which add, block or specifically activate only one of the two receptors in the body to combat the growth of cancer cells."

Williams' collaborators included CNRCS director Jan-Åke Gustafsson, UH biology and biochemistry professor Stuart Dryer, research assistant professors Anders Ström and Christoforos Thomas, and graduate students Karin Edvardsson, Claudia Alvarez-Baron and Philip Jonsson. The research was funded in part with a grant from the Texas Emerging Technology Fund, as well as grants from the Lars Hierta Memorial Foundation, the Magnus Bergvall Foundation, the Swedish Cancer Society and the Robert A. Welch Foundation.

Molecular Endocrinology provides a forum for papers devoted to describing molecular mechanisms by which hormones and related compounds, like receptors, regulate function. To read an abstract of the June cover story titled "Estrogen Receptor {beta} Induces Anti-inflammatory and Antitumorigenic Networks in Colon Cancer Cells," visit http://mend.endojournals.org/cgi/content/abstract/me.2010-0452v1. For the August abstract titled "The Two-Pore Domain Potassium Channel KCNK5: Induction by Estrogen Receptor {alpha} and Role in Proliferation of Breast Cancer Cells," visit http://mend.endojournals.org/content/25/8/1326.abstract.

Editorial Note: High-resolution photos of Cecilia Williams are available to media by contacting Lisa Merkl.

About the University of Houston

The University of Houston is a Carnegie-designated Tier One public research university recognized by The Princeton Review as one of the nation's best colleges for undergraduate education. UH serves the globally competitive Houston and Gulf Coast Region by providing world-class faculty, experiential learning and strategic industry partnerships. Located in the nation's fourth-largest city, UH serves more than 38,500 students in the most ethnically and culturally diverse region in the country.

About the College of Natural Sciences and Mathematics

The UH College of Natural Sciences and Mathematics, with 181 ranked faculty and approximately 4,500 students, offers bachelor's, master's and doctoral degrees in the natural sciences, computational sciences and mathematics. Faculty members in the departments of biology and biochemistry, chemistry, computer science, earth and atmospheric sciences, mathematics and physics conduct internationally recognized research in collaboration with industry, Texas Medical Center institutions, NASA and others worldwide.

For more information about UH, visit the university's Newsroom at http://www.uh.edu/news-events/.

To receive UH science news via e-mail, sign up for UH-SciNews at http://www.uh.edu/news-events/mailing-lists/sciencelistserv/index.php.

For additional news alerts about UH, follow us on Facebook at http://www.facebook.com/UHNewsEvents and Twitter at http://twitter.com/UH_News.

Lisa Merkl | EurekAlert!
Further information:
http://www.uh.edu

More articles from Health and Medicine:

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

New Study Will Help Find the Best Locations for Thermal Power Stations in Iceland

19.01.2017 | Earth Sciences

Not of Divided Mind

19.01.2017 | Life Sciences

Molecule flash mob

19.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>