New research from the Trudeau Institute may help in the ongoing fight against tuberculosis. Dr. Andrea Cooper's lab has discovered a connection between the development of new lymphoid tissue within the lung and protection against the disease. The new data will be published in the November 1 print issue of The Journal of Immunology (Vol. 187, Num. 10) and is available now online ahead of print.
Tuberculosis (TB for short) is a deadly infectious disease caused by infection with Mycobacterium tuberculosis that affects many people throughout the world. Tuberculosis normally attacks the lungs, but can also affect other parts of the body. It is spread through the air when people with active TB infection cough, sneeze or otherwise transmit their saliva through the air. Left untreated, TB can kill more than 50 percent of its victims.
"In the model examined by my laboratory, the absence of a specific cytokine resulted in poor development of new lymphoid tissue," said Dr. Cooper. "There was an associated loss of a molecule that helps recruit protective cells from the blood to the site of infection within the lung. Although this lymphoid tissue has been seen in tuberculosis lesions in the lung in the past, this is the first time that this part of the immune response has been associated with an active role in protection against tuberculosis."
By understanding how different components of the immune response control the bacteria that cause tuberculosis, public health officials/health practitioners will be better positioned to protect against the disease with a combination of vaccination, immunotherapeutics and drugs. The new findings could prove particularly useful as cells within this lymphoid tissue have not been previously targeted by vaccination and may provide novel avenues to improve current vaccines.
The research was performed by current and past members of the Trudeau Institute, including scientists from the University of Pittsburgh and the University of Rochester. Dr. Shabaana Khader, Dr. Javier Rangel-Moreno and Dr. Troy Randall were also involved with the study.
Dr. Cooper's studies are funded by the Trudeau Institute and grants from the National Institutes of Health.
About the Trudeau Institute
The Trudeau Institute is an independent, not-for-profit, biomedical research organization, whose scientific mission is to make breakthrough discoveries leading to improved human health. Trudeau researchers are identifying the basic mechanisms used by the immune system to combat viruses like influenza, mycobacteria, such as tuberculosis, parasites and cancer, so that better vaccines and therapies can be developed for fighting deadly disease.
The research is supported by government grants and philanthropic contributions.
Kim Godreau | EurekAlert!
'Exciting' discovery on path to develop new type of vaccine to treat global viruses
18.09.2017 | University of Southampton
A new approach to high insulin levels
18.09.2017 | Schweizerischer Nationalfonds SNF
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.
MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...
Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...
Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.
Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
19.09.2017 | Event News
19.09.2017 | Physics and Astronomy
19.09.2017 | Power and Electrical Engineering