Sugar helping map new ground against deadly bug
A potential vaccine against bacteria that cause serious gastric disorders including stomach cancer may be a step closer following a pioneering study by a University of Guelph chemist.
In the first published study of its kind, a team led by Prof. Mario Monteiro, Department of Chemistry, found a carbohydrate-based antigen caused mice to develop antibodies against a common bacterium linked to gastric cancer.
"This is the first jab at a sugar-based vaccine against Helicobacter pylori," said Monteiro, who completed the study with former undergrad student Stacey Britton.
Their study was published recently in the journal Vaccine.
H. pylori is among numerous risk factors for stomach cancer. About half of the world's population has been infected by the bacterium during their lifetime. In Canada, the bug is especially prevalent in Aboriginal communities. It can cause gastritis and ulcers. Most infections are handled by antibiotics, but a vaccine would improve current treatment, said Monteiro.
Many scientists study potential vaccines based on proteins to prevent or control infection. Since arriving at Guelph in 2004, Monteiro has studied more complicated conjugates containing both proteins and sugars.
The Guelph researchers used a single bacterial strain in mice to induce an immune response against various strains of the bacteria.
He has studied sugar-based vaccines against two other gastric pathogens: Campylobacter jejuni, which causes travellers' diarrhea, and C. difficile, which causes antibiotic-associated diarrhea. He plans to begin studies of conjugates for use against tuberculosis.
Mario Monteiro | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...