Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Storage Time for Cartilage Transplant Tissue Doubled by MU Researchers

14.03.2012
New method will increase likelihood of success in cartilage grafting procedures
For years, doctors have been able to treat defects in joint cartilage by grafting cartilage donated from cadavers into patients’ bad joints. Using current methods, donated cartilage can be stored for 28 days for a transplant before the tissue becomes too degraded to transplant into a patient. Now, researchers from the University of Missouri have found a way to store donated cartilage more than twice as long.

“Currently, nearly 80 percent of all donated tissue has to be discarded because it deteriorates before a transplant bank can find a match with a patient who needs a transplant,” James Cook, a researcher from the MU College of Veterinary Medicine and the William C. and Kathryn E. Allen Distinguished Professor in Orthopaedic Surgery, said. “By more than doubling the time we can store tissue, the odds of matching the tissue with a recipient are greatly increased.”

In a study due to be published in the Journal of Knee Surgery, Cook and Aaron Stoker from MU’s Comparative Orthopaedic Laboratory, Clark Hung and Eric Lima from Columbia University, and James Stannard, the J. Vernon Luck Sr. Distinguished Professor in Orthopaedic Surgery in the MU School of Medicine, tested tissue using their patented system, which includes storing the tissue at room temperature in a specially designed container and storage solution. The researchers found that their system preserved transplant-quality tissue for as long as 63 days. The collaborative team of researchers also developed a way to monitor the quality of the stored tissue simply by testing a few drops of their patented storage solution.

“Not only have we been able to increase maximum tissue storage time from 28 to 63 days, but tissue stored for 63 days using our new method is of much higher quality than tissue on its 28th day of storage using the current method,” Cook said. “This is important because the quality of the tissue at the time of a transplant procedure markedly affects long-term success for the patient.”

The new storage system can be used on many different types of joint cartilage, including knee, hip, shoulder, elbow, and ankle tissue. Doctors can use this tissue to treat a number of different defects including traumatic injuries, sports-related injuries, developmental defects and some types of arthritis-related cartilage loss. These tissue transplants can last for 15 years or more before needing to be replaced with traditional metal and plastic joint replacements. Cartilage grafting has been an FDA approved practice for years, so the new MU storage system is currently under licensing negotiation for clinical application. Cook is optimistic that the first grafts stored using the new system will be available to help patients at the Missouri Orthopaedic Institute within a year.

This study is a result of collaboration through Mizzou Advantage. The Mizzou Advantage was created to increase MU’s visibility, impact and stature in higher education, locally, statewide, nationally and around the world. Mizzou Advantage is a program that focuses on four areas of strength: food for the future, media of the future, one health/one medicine, and sustainable energy. The goals of Mizzou Advantage are to strengthen existing faculty networks, create new networks and propel Mizzou’s research, instruction and other activities to the next level.

Nathan Hurst | EurekAlert!
Further information:
http://www.missouri.edu

More articles from Health and Medicine:

nachricht The end of pneumonia? New vaccine offers hope
23.10.2017 | University at Buffalo

nachricht Scientists track ovarian cancers to site of origin: Fallopian tubes
23.10.2017 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>