"Previous studies have shown that men taking statins seem to have a lower incidence of advanced prostate cancer, but the mechanisms by which statins might be affecting the prostate remained largely unknown," said Lionel Bañez, M.D., a researcher in the Duke Prostate Center and lead investigator on this study.
"We looked at tumor samples and found that men who were on statins had a 72 percent reduction in risk for tumor inflammation, and we believe this might play a role in the connection between prostate cancer and statin use."
The researchers presented their finding at the American Urological Association's annual meeting on April 26, 2009, and the study was selected to be part of the meeting's press program on April 27, 2009. The study was funded by the United States Department of Defense and the American Urological Association Foundation.
The researchers looked at pathological information from the tumors of 254 men who underwent radical prostatectomy – or surgery to remove the entire prostate – as a treatment for prostate cancer at the Durham Veterans Affairs Medical Center between 1993 and 2004. The tissue was graded by a pathologist for inflammation on a scale of 0 to 2: 0 for no inflammation, 1 for mild inflammation (less than 10 percent of the tumor) and 2 for marked inflammation (greater than 10 percent of the tumor).
"This finding provides a potential mechanism of action for statins' effects on prostate cancer biology," Bañez said.
Other Duke Prostate Center research has found that inflammation in tumors is associated with recurrent prostate cancer, so these two findings, taken together, provide more impetus for considering the use of statins to possibly control or prevent prostate cancer, Bañez said.
"We're not there yet, though," said Stephen Freedland, M.D., a urologist at Duke and senior investigator on this study. "Though very promising, more work has to be done before we recommend that men go out and start taking statins as a path toward better prostate health."
Other researchers involved in this study include Jayakrishnan Jayachandran, Joseph Klink, Amy Lark, Leah Gerber and Robin Vollmer.
Lauren Shaftel Williams | EurekAlert!
Researchers show p300 protein may suppress leukemia in MDS patients
28.03.2017 | University of Miami Miller School of Medicine
When writing interferes with hearing
28.03.2017 | Université de Genève
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Life Sciences
28.03.2017 | Medical Engineering
27.03.2017 | Earth Sciences