Those who smoke and drink heavily may develop pancreatic cancer at an earlier age than those who don't, according to a study led by a University of Michigan Health System gastroenterologist.
In the study, published in the American Journal of Gastroenterology, heavy smokers with pancreatic cancer were diagnosed around age 62 and heavy drinkers at age 61 – almost a decade earlier than the average age of 72.
Smoking is a strong risk factor for pancreatic cancer and alcohol has been shown to cause oxidative damage to the pancreas, which sets the stage for the inflammatory pathways that can lead to cancer.
The findings only indicate these habits can lead to developing pancreatic cancer earlier in life.
The study of 811 pancreatic cancer patients from the multicenter, international database Pancreatic Cancer Collaborative Registry does not prove the habits caused cancer.
The study does make a step toward understanding at what age screening for pancreatic cancer should begin – once widespread screening is available.
"As screening programs are developed, an understanding of how personal features influence the age of presentation will be important to optimize the timing of those screenings," says lead study author and gastroenterologist Michelle Anderson, M.D., assistant professor of internal medicine at the University of Michigan Health System. Detecting pancreatic cancer early is difficult and contributes to the poor survival rates. By the time pancreatic cancer is diagnosed, it is frequently at an advanced stage and has spread to other organs.
Currently there are no tests available to easily find it in people who do not have symptoms. In the study, heavy smokers were defined as those who had more than a pack per day, and heavy drinking was measured at more than 39 grams a day, or about three average drinks per day.
Beer drinkers presented with pancreatic cancer earlier than those who drank other types of alcohol, such as wine or hard liquor although when adjusted for the amount of alcohol consumed, the type of alcohol did not affect the age of presentation.
The good news is that the harmful effects of heavy drinking and smoking can be resolved . After 10 years, former smokers and drinkers who quit their habits faced no extra risk of earlier diagnosis.
The registry used for the study gathers information on patients with pancreatic cancer and those at high-risk for developing pancreatic cancer.
Patient data was collected from University of Nebraska Medical Center, Omaha, Neb.; University of Genoa, Italy; Creighton University School of Medicine, Omaha, Neb.; University of Pittsburgh Medical Center; NorthShore University Health System, Evanston, Ill.; University of Chicago, Chicago, Ill.; University of Alabama at Birmingham, Ala.; and the University of Michigan Health System, Ann Arbor, Mich.
Funding: This work was supported by the following grants: NIH K23 DK082097, NCI T32 CA 083654, NIH R01 CA140940, and Italian Ministry of Health DGRST.4/4235-P1.9.A.B.
Reference: "Alcohol and Tobacco Lower the Age of Presentation in Sporadic Pancreatic Cancer in a Dose-Dependent Manner: A Multicenter Study," American Journal of Gastroenterology.
On the Web
Pancreatic Cancer Collaborative Registry (PCCR) http://pccrproject.com
University of Michigan Division of Gastroenterology http://www.uofmhealth.org/medical-services/digestive%20health%20and%20liver%20disease
University of Michigan Comprehensive Cancer Center www.mcancer.org
Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania
The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Trade Fair News
16.01.2017 | Architecture and Construction
13.01.2017 | Life Sciences