Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Smart lasers could make cancer biopsies painless, help speed new drugs to market

01.02.2011
Biopsies in the future may be painless and noninvasive, thanks to smart laser technology being developed at Michigan State University.

To test for skin cancer, patients today must endure doctors cutting away a sliver of skin, sending the biopsy to a lab and anxiously awaiting the results. Using laser microscopes that deploy rapid, ultra-short pulses to identify molecules, doctors may soon have the tools to painlessly scan a patient's troublesome mole and review the results on the spot, said Marcos Dantus.

The results touting this new molecule-selective technology can be found in the current issue of Nature Photonics, which Dantus co-authored with Sunney Xie of Harvard University.

"Smart lasers allow us to selectively excite compounds – even ones with small spectroscopic differences," said Dantus. "We can shape the pulse of the lasers, excite one compound or another based on their vibrational signatures, and this gives us excellent contrast."

In the past, researchers could approach this level of contrast by introducing fluorescent compounds. With the breakthrough using stimulated Raman scattering microscopy, fluorescent markers are unnecessary.

"Label-free molecular imaging has been the holy grail in medicine," Dantus said. "SRS imaging gives greater specificity and the ability to map a particular chemical species in the presence of an interfering species, such as cholesterol in the presence of lipids."

Additional potential applications include allowing researchers to closely examine how compounds penetrate skin and hair. Smart lasers also can better identify how drugs penetrate tissue and how drugs and tissue interact, thus mitigating the chances of potential side effects and helping reduce the time required to bring new drugs to market.

Dantus also is using smart laser imaging technology at MSU for detecting traces of hazardous substances from a distance.

"The ability to image with molecular specificity and sensitivity opens a number of applications in medicine as well as in homeland security," he said.

Collaboration for the paper began when Harvard graduate student Christian Freudiger contacted BioPhotonic Solutions, a high-tech company Dantus launched in 2003 based on his research at MSU. Dantus was not only able to provide the laser pulse shaper Harvard needed to conduct the research, but he also was able to lend his expertise as well as the support of his MSU laboratory, Dantus said.

"I like to say that we enable technology," he said. "Controlling ultrashort pulses, which once required Ph.D. experts, can now be done with push-button simplicity by a small computer-controlled box. This instrument is now being used in the most prestigious research laboratories in the world."

Dantus' research is funded in part by the National Science Foundation.

Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world's most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

Layne Cameron | EurekAlert!
Further information:
http://www.msu.edu

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

NASA's Fermi catches gamma-ray flashes from tropical storms

25.04.2017 | Physics and Astronomy

Researchers invent process to make sustainable rubber, plastics

25.04.2017 | Materials Sciences

Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017

25.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>