Peripheral arterial disease (PAD) occurs when plaque, a combination of fat, cholesterol and other substances, builds up in the arteries, limiting the flow of oxygen-rich blood throughout the body. PAD usually affects arteries that carry blood to the legs, causing poor circulation, discomfort and pain. More than eight million Americans have PAD, according to the American Heart Association.
According to the National Heart, Lung and Blood Institute, coronary artery disease is the most common type of heart disease and the leading cause of death in the U.S.
"PAD patients, including those experiencing no symptoms of heart disease, are known to be at high risk for cardiovascular events such as a heart attack or stroke," said Rozemarijn Vliegenthart Proenca, M.D., Ph.D., radiology resident at the University Medical Center Groningen in the Netherlands. "The purpose of our clinical trial was to investigate whether noninvasive imaging of the heart and subsequent treatment of PAD patients result in a decrease in cardiac events compared to standard care."
In the clinical trial, a total of 231 PAD patients from four participating hospitals in the Netherlands were divided into one of two groups: one in which 108 patients received standard care—consisting of lifestyle changes and medication—for their condition, and a second group in which 115 patients underwent cardiac imaging of the heart in addition to standard care.
"With new, noninvasive cardiac imaging techniques, asymptomatic coronary atherosclerosis can be readily detected and treated," Dr. Vliegenthart Proenca said.
Among the 115 patients who received cardiac imaging, computed tomography (CT) revealed that 53, or 46 percent, had at least one significant narrowing of a coronary artery. Of those 53 patients, 22 had significant narrowing in the left main coronary artery or its equivalent, and were referred for treatment. Eight of those patients subsequently had bypass surgery, and three underwent coronary angiography with stent placement. The remaining patients were treated with medication.
Cardiac stress MRI was then performed on 76 patients. Cardiac stress MRI, in which a drug is infused into the patient's bloodstream to make the heart work harder, helps determine if the heart muscle is receiving adequate blood flow. Results of the cardiac stress MRI exams identified two additional patients with signs of coronary artery disease, one of whom underwent angiography and stent placement.
In total, 24 (21 percent) of the 115 patients who underwent imaging had evidence of asymptomatic but severe coronary artery disease that required additional treatment.
"In PAD patients experiencing no cardiac symptoms, we found a strikingly high rate of severe coronary artery disease," Dr. Vliegenthart Proenca said. "The results of our trial stress that PAD patients without a history of cardiac symptoms should undergo extensive cardiovascular risk factor management."
Coauthors are Alexander de Vos, M.D., Ph.D., Matthijs Oudkerk, M.D., Ph.D., Mathias Prokop, M.D., Ph.D., Michiel Bots, M.D., Ph.D., Willem Mali, M.D., Ph.D., Annemarieke Rutten, M.D., Ph.D., Gonda de Jonge, M.D., Daniel Lubbers, M.D., Jan van den Dungen, M.D., Ph.D., Maarten Cramer, M.D., Ph.D., Pieter Doevendans, M.D., Ph.D., Benno Rensing, M.D., Ph.D., Hester van der Zaag-Loonen, M.D., Ph.D., and Felix Zijlstra, M.D., Ph.D.
Note: Copies of RSNA 2009 news releases and electronic images will be available online at RSNA.org/press09 beginning Monday, Nov. 30.
RSNA is an association of more than 44,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. The Society is based in Oak Brook, Ill. (RSNA.org)
Editor's note: The data in these releases may differ from those in the printed abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.
For patient-friendly information on x-rays, visit RadiologyInfo.org.
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News