Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Safety of stored blood among chief concerns for transfusion medicine community

15.04.2011
Medical literature addresses possible adverse effects with older red cells; delivery of oxygen

In light of recent studies that suggest the use of stored blood during transfusions may cause adverse effects in patients, the National Heart, Lung, and Blood Institute (NHLBI) funded a number of research projects to examine the safety of transfusing older red cells and the impact of stored blood on respiratory gases.

These papers discussing potential adverse effects of stored blood and related concerns for oxygen delivery by transfusion are now available online in TRANSFUSION, a journal published by Wiley-Blackwell on behalf of AABB.

Blood banks are responsible for the collection, testing, and storage of blood to be used by the nearly 5 million Americans who receive blood transfusions annually. When patients experience a loss of blood due to illness or trauma, transfusions of whole blood or individual components (red cells, white cells, platelets, and plasma) are administered to restore blood volume to adequate levels. According to the 2007 National Blood Collection and Utilization Survey (NBCUS) Report, 14.7 million units of blood were administered in the U.S., with a total of 72,000 transfusion-related adverse reactions in the prior year.

"The most critical issue facing transfusion medicine is whether or not stored (older) blood is less safe than fresher blood," explains Paul M. Ness, M.D., Director of Transfusion Medicine at Johns Hopkins Medical Institute in Baltimore, MD, and Editor-in-Chief of TRANSFUSION. "Although emerging infectious disease risks and transfusion reactions are important concerns, there is nothing more imperative to our patients than making sure the methods we use to collect and store red cells do not impair their transport of vital respiratory gases."

Current Food and Drug Administration (FDA) standards state that red cells may be stored under refrigeration for a maximum of 42 days, or frozen for up to ten years. NBCUS 2007 data reported the mean age of stored red cells at the time of transfusion was 16 days. Medical evidence, however, has not been able to conclusively determine if stored blood adversely affects patients' health. In one prior study, trauma patients who received red cells stored beyond two weeks had a significantly increased risk of mortality compared to those transfused with fresher blood (Weinberg et al., 2010). Conversely, a study by Edgren et al., analyzed close to 405,000 transfusions between 1995 and 2002 and found no significant association between age of blood and seven-day mortality.

Controlled clinical trials in cardiac surgery and intensive care units are under way, and are expected to provide the transfusion community with critical data regarding the adverse effects of stored blood use. "Findings from these trials will not be reported for several years," said Dr. Ness. "Our early publication of the NHLBI grant program studies provides the transfusion community with a head start in learning more about what makes stored blood old, and provides advance opportunity for commercial industry to develop improved methods of blood storage that will mitigate adverse effects in patients."

These studies are published in TRANSFUSION. Media wishing to receive a PDF of the articles may contact healthnews@wiley.com.

Full Citations

Editorial: "Does Transfusion of Stored Red Cells Cause Clinically Important Adverse Effects? A Critical Question in Search of an Answer and a Plan." Paul Ness. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03121.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03121.x

Editorial: "The 2010 Tibor Greenwalt Lecture The Air We Breathe--Three Vital Respiratory Gases and The Red Cell: Oxygen, Nitric Oxide, and Carbon Dioxide." Walter H. Dzik. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03114.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03114.x

Article: "Red Blood Cell Age and Potentiation of Transfusion-Related Pathology in Trauma Patients." Jordan A. Weinberg, Scott R. Barnum, and Rakesh P. Patel. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03098.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03098.x

Article: "New Frontiers in Transfusion Biology: Identification and Significance of Mediators of Morbidity and Mortality in Stored Red Blood Cells." Katie Grimshaw, Julie Sahler, Sherry L. Spinelli, Richard P. Phipps and Neil Blumberg.TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03095.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03095.x

Article: "Microparticles in Stored Red Blood Cells as Potential Mediators of Transfusion Complications." Wenche Jy, Marco Ricci, Sherry Shariatmadar, Orlando Gomez- Marin, Lawrence H. Horstman,and Yeon S. Ahn. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03099.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03099.x

Article: "Storage Lesion: Role of Red Cell Breakdown." Daniel B. Kim-Shapiro, Janet Lee, Mark T. Gladwin. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03100.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03100.x

Article: "Properties of Stored RBCs: Understanding Immune and Vascular Reactivity." Philip C. Spinella, Rosemary L. Sparrow, John R. Hess, Philip J. Norris. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03103.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03103.x

Article: "Insufficient Nitric Oxide Bioavailability: A Hypothesis to Explain Adverse Effects of Red Blood Cell Transfusion." John D. Roback, Robert Neuman, Arshed Quyyumi, and Roy Sutliff. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03094.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03094.x

Article: "Harmful Effects of Transfusion of Older Stored Red Blood Cells: Iron And Inflammation." Eldad A. Hod and Steven L. Spitalnik. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03096.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03096.x

Article: "The Transfusion Problem: Role of Aberrant S-Nitrosylation." James D. Reynolds, Douglas T. Hess, and Jonathan S. Stamler. TRANSFUSION; Published Online: April 15, 2011 (DOI: 10.1111/j.1537-2995.2011.03097.x); Print Issue Date: April 2011. http://doi.wiley.com/10.1111/j.1537-2995.2011.03097.x

About the Journal

TRANSFUSION is the official journal of AABB and the foremost publication in the world for new information regarding transfusion medicine. Written by and for members of AABB and other health-care workers, TRANSFUSION reports on the latest technical advances, discusses opposing viewpoints regarding controversial issues, and presents key conference proceedings. In addition to blood banking and transfusion medicine topics, TRANSFUSION presents submissions concerning tissue transplantation and hematopoietic, cellular, and gene therapies. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1537-2995/issues.

About AABB

AABB (formerly the American Association of Blood Banks) is an international, not-for-profit association representing individuals and institutions involved in the field of transfusion medicine and cellular therapies. The association is committed to improving health by developing and delivering standards, accreditation and educational programs that focus on optimizing patient and donor care and safety. AABB membership consists of nearly 2,000 institutions and 8,000 individuals, including physicians, nurses, scientists, researchers, administrators, medical technologists and other health care providers. Members are located in more than 80 countries. For more information, please visit www.aabb.org.

About Wiley-Blackwell

Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our new online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.

Dawn Peters | EurekAlert!
Further information:
http://www.wileyblackwell.com

More articles from Health and Medicine:

nachricht Usher syndrome: Gene therapy restores hearing and balance
25.09.2017 | Institut Pasteur

nachricht MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The fastest light-driven current source

Controlling electronic current is essential to modern electronics, as data and signals are transferred by streams of electrons which are controlled at high speed. Demands on transmission speeds are also increasing as technology develops. Scientists from the Chair of Laser Physics and the Chair of Applied Physics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) have succeeded in switching on a current with a desired direction in graphene using a single laser pulse within a femtosecond ¬¬ – a femtosecond corresponds to the millionth part of a billionth of a second. This is more than a thousand times faster compared to the most efficient transistors today.

Graphene is up to the job

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Nerves control the body’s bacterial community

26.09.2017 | Life Sciences

Four elements make 2-D optical platform

26.09.2017 | Physics and Astronomy

Goodbye, login. Hello, heart scan

26.09.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>