Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Computers learn how to create drugs of the future

02.05.2002


The key role of computer technology in the fine-tuning of drug development and design will be considered by Professor Stephen Muggleton of Imperial College, London in his inaugural lecture, Models of Mind and Models of Body, today.



The new Professor of Bioinformatics in the Department of Computing will focus on how machine learning and logic programming can reduce the high costs of drug development in the pharmaceutical industry.

The pharmaceutical industry is increasingly overwhelmed by a large volumes of data generated both internally as a result of screening tests and combinatorial chemistry, and externally from sources such as the Human Genome Project. The majority of drug development is dependant on sifting through this information and using it to identify slight improvements in variants of patented active drugs.


Applying inductive logic programming (ILP), a research area formed at the intersection of machine learning and logic programming, Professor Muggleton and his team have shown that it is possible to construct rules that accurately predict the activity of untried drugs.

"Research and development in the pharmaceutical industry involves laboratories of chemists synthesising and testing hundreds of compounds often at great expense," said Professor Muggleton

"It is now possible to construct rules that predict whether drugs will work from examples of drugs with known medicinal activity. The accuracy of the rules has been shown to be slightly higher than traditional statistical methods used in drug development."

Recent research successes in the Computational Bioinformatics Laboratory led by Professor Muggleton include a collaboration with the pharmaceutical company SmithKline Beecham (now GlaxoSmithKline) that has yielded a machine-learning model that can identify novel neuropeptides at over 100 times the rate of the GSK in-house model. Working with the Universities of Manchester and Aberystwyth, researchers led by Professor Muggleton have developed a system that automatically suggests experiments for determining the function of genes in yeast, an important model organism in biological research.

"During the 21st century, it is already clear that computers will play an increasingly central role in supporting the fundamental formulation and testing of scientific hypotheses. The automatic construction and testing of hypotheses and their eventual incorporation into accepted knowledge-bases will require an ability to handle incomplete, incorrect and imprecise information," he added.

Judith H Moore | alphagalileo

More articles from Health and Medicine:

nachricht Improving memory with magnets
28.03.2017 | McGill University

nachricht Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Transport of molecular motors into cilia

28.03.2017 | Life Sciences

A novel hybrid UAV that may change the way people operate drones

28.03.2017 | Information Technology

NASA spacecraft investigate clues in radiation belts

28.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>